2021
DOI: 10.1038/s41416-021-01271-7
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Background Gastric cancer (GC) with hepatic metastasis has a poor prognosis. Understanding the molecular mechanisms involved in hepatic metastasis may contribute to the development of sensitive diagnostic biomarkers and novel therapeutic strategies. Methods We performed transcriptome analysis of surgically resected specimens from patients with advanced GC. One of the genes identified as specifically associated with hepatic metastasis was selected f… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
11
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
7
1
1

Relationship

1
8

Authors

Journals

citations
Cited by 17 publications
(12 citation statements)
references
References 63 publications
1
11
0
Order By: Relevance
“…P53 mutations were reported as a driver of metastasis signalling pathways ( 37 ). Most circulating cancer cells die via PANoptosis, including anoikis, pyroptosis, apoptosis, and necroptosis, within the bloodstream ( 38 , 39 ). Avoiding PANoptosis is essential for circulating cancer cells adhering to endothelial cells, extravasating and cloning in distant tissues.…”
Section: Discussionmentioning
confidence: 99%
“…P53 mutations were reported as a driver of metastasis signalling pathways ( 37 ). Most circulating cancer cells die via PANoptosis, including anoikis, pyroptosis, apoptosis, and necroptosis, within the bloodstream ( 38 , 39 ). Avoiding PANoptosis is essential for circulating cancer cells adhering to endothelial cells, extravasating and cloning in distant tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Under normal circumstances, ETNK2 is highly expressed in the liver and reproductive tissues [13]. Some studies have confirmed that increased expression of ETNK2 is closely related to liver metastasis in gastric cancer [16], lung adenocarcinoma [18], and lung squamous cell carcinoma [18]. At present, there is no literature concerning the relationship between ETNK2 and thyroid malignant tumours, so we investigated this relationship to explore new molecular markers of PTC.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have shown that upregulation of ETNK2 in GC enhances liver metastasis. This may be related to the dysregulation of Ivyspring International Publisher p53-Bcl-2-related apoptosis [16]. Studies have shown that methylation of the ETNK2 gene promoter helps laryngeal cancer cells resist radiation [17].…”
Section: Introductionmentioning
confidence: 99%
“…ETNK2 is an ethanolamine kinase that has enhanced expression in gastric, non-small cell lung, and prostate cancers ( Miwa et al, 2021 ). ETNK2 promotes liver metastasis of gastric cancer by inhibiting the p53-Bcl2 apoptotic pathway, resulting in a poor prognosis.…”
Section: Discussionmentioning
confidence: 99%