Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions

Frens, G.

doi:10.1038/physci241020a0

Cited by 7,153 publications

(5,182 citation statements)

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“…12 nm Au nanoparticles were prepared following the Turkevich and Frens method. 51,52 Gold (III) chloride trihydrate (12.5 mg dissolved in 1ml ultrapure water) was added to a boiling solution of trisodium citrate (50 mg in 149 ml ultrapure water). The reaction proceeded under reflux with rapid stirring for 30 minutes, resulting in a dark red coloured solution.…”

Section: Nanoparticle Synthesismentioning

confidence: 99%

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

et al. 2013

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The Blood-Brain Barrier (BBB) is a selective barrier, which controls and limits access to the central nervous system (CNS). The selectivity of the BBB relies on specialized characteristics of the endothelial cells that line the microvasculature, including the expression of intercellular tight junctions, which limit paracellular permeability. Several reports suggest that nanoparticles have a unique capacity to cross the BBB. However, direct evidence of nanoparticle transcytosis is difficult to obtain, and we found that typical transport studies present several limitations when applied to nanoparticles. In order to investigate the capacity of nanoparticles to access and transport across the BBB, several different nanomaterials, including silica, titania and albumin-or transferrinconjugated gold nanoparticles of different sizes, were exposed to a human in vitro BBB model of endothelial hCMEC/D3 cells. Extensive transmission electron microscopy imaging was applied in order to describe nanoparticle endocytosis and typical intracellular localisation, as well as to look for evidence of eventual transcytosis. Our results show that all of the nanoparticles were internalised, to different extents, by the BBB model and accumulated along the endo-lysosomal pathway. Rare events suggestive of nanoparticle transcytosis were also observed for several of the tested materials.

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Section: Nanoparticle Synthesismentioning

confidence: 99%

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

et al. 2013

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“…Citrate-capped gold nanoparticles were prepared according to the Frens' method by means of the chemical reduction of HAuCl 4 by citrate in the liquid phase [29]. Briefly, 200 mL aqueous solution of 1 mM HAuCl 4 was first brought to boil with vigorous stirring.…”

Section: Gold Nanoparticles Synthesismentioning

confidence: 99%

Colorimetric sensing of copper(II) based on catalytic etching of gold nanoparticles

Liu

Chen

Wang

et al. 2013

Talanta

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“…On the basis of previous reports [24], a solution of the AuNPs was prepared by the chemical reduction of metal salt precursor (hydrogen tetrachloroaurate, HAuCl 4 ) in a liquid solution. A solution of HAuCl 4 (0.35 mM, 50 mL) was heated to a boil before adding 34.0 mM trisodium citrate (0.8 mL).…”

Section: Synthesis Of Aunpsmentioning

confidence: 99%

Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry

Lin

et al. 2009

J. Am. Soc. Mass Spectrom.

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Citrate-capped gold nanoparticles (AuNPs) serve as matrices for the determination of biomolecules in a high-salt solution through matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In the case of using 2,5-dihydroxybenzoic acid (2,5-DHB) as a matrix, the signal intensities of neutral steroids were severely suppressed in a high-salt solution. A high concentration of NaCl caused the formation of the sodium adduct ions during the desorption/ionization process, resulting in a decrease of the signal intensities of the protonated ions. In comparison, by applying AuNP-assisted LDI-TOF-MS, the signal intensities of neutral steroids remained almost constant when the concentration of NaCl was increased to 500 mM. Because the use of citrate-capped AuNPs as matrices primarily offers alkali metal ion adducts, AuNP matrices have a higher tolerance to high NaCl concentrations relative to that of 2,5-DHB matrices. The relevant phenomena are also discovered in the case of analysis of neutral carbohydrate, monosialoganglioside, indolamine, and angiotensin I. The quantification of small molecules in a high-salt solution has been accomplished by AuNP-assisted LDI-TOF-MS coupled to a unique sample preparation, in which samples are deposited onto the sample plate before AuNPs. The present method has been further applied to the determination of urea, creatinine, uric acid, and glucose in a urine sample. (J Am Soc Mass Spectrom 2009, 20, 875-882)

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Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions

Cited by 7,153 publications

References 1 publication

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

Colorimetric sensing of copper(II) based on catalytic etching of gold nanoparticles

Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry

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