2008
DOI: 10.1038/onc.2008.23
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Abstract: FoxO transcription factors are an evolutionary conserved subfamily of the forkhead transcription factors, characterized by the forkhead DNA-binding domain. FoxO factors regulate a number of cellular processes involved in cell-fate decisions in a cell-type-and environment-specific manner, including metabolism, differentiation, apoptosis and proliferation. A key mechanism by which FoxO determines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequence of FoxO deregulatio… Show more

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Cited by 158 publications
(135 citation statements)
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“…The resistant REH cells expressed comparable levels of FOXO3a, P-FOXO3a (S315), P-FOXO3a (T32), PFOXO3a (S253) before and after dexamethasone treatment. In contrast, in the sensitive cells, RS4;11 and SUP-B15, dexamethasone caused the downregulation of FOXO3a phosphorylation at Thr-32, Ser-253, and Ser-315, indicative of FOXO3a nuclear relocation and activation (4,36). In response to dexamethasone, FOXO3a activation in the sensitive cells was further confirmed by the increased expression of the FOXO3a target Bim and the consequent activation of apoptosis, as evidenced by caspase-3, -7, and -9 cleavage and activation.…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…The resistant REH cells expressed comparable levels of FOXO3a, P-FOXO3a (S315), P-FOXO3a (T32), PFOXO3a (S253) before and after dexamethasone treatment. In contrast, in the sensitive cells, RS4;11 and SUP-B15, dexamethasone caused the downregulation of FOXO3a phosphorylation at Thr-32, Ser-253, and Ser-315, indicative of FOXO3a nuclear relocation and activation (4,36). In response to dexamethasone, FOXO3a activation in the sensitive cells was further confirmed by the increased expression of the FOXO3a target Bim and the consequent activation of apoptosis, as evidenced by caspase-3, -7, and -9 cleavage and activation.…”
Section: Discussionmentioning
confidence: 90%
“…FOXO3a plays an important role in proliferation, apoptosis, autophagy, metabolism, inflammation, differentiation, and stress resistance (3,4). The stability, subcellular localization, the DNA-binding affinity, and the transcriptional activity of FOXO3a are primarily regulated by a complex array of posttranslational modifications (5).…”
Section: Introductionmentioning
confidence: 99%
“…They function in cell cycle arrest, differentiation and anti-oxidation response (Arden, 2008;Ho et al, 2008;Sedding, 2008). FOXO3 suppresses estrogendependent breast cancer cell proliferation and tumorigenesis (Zou et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Potential cancer preventive actions of 1,25D signaling through the VDR can be explained in part by the direct interaction of the VDR with FoxO transcription factors, leading to 1,25D-stimulated FoxO DNA-binding and target gene regulation (19). FoxO proteins regulate cell proliferation, differentiation, and metabolism and control longevity (20)(21)(22)(23). Serial ablation of foxo genes in mice revealed that they are bona fide tumor suppressors (24)(25)(26).…”
mentioning
confidence: 99%