2007
DOI: 10.1038/nrn2214
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Abstract: At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. I… Show more

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Cited by 1,226 publications
(923 citation statements)
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References 117 publications
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“…Heme oxygenase-1 (HO-1), also referred to as Hsp32, belongs to the Hsp family and protects brain cells from oxidative stress by degrading toxic heme into free iron, carbon monoxide and biliverdin [17,24]. This latter is then reduced by biliverdin reductase (BVR) into bilirubin (BR), a linear tetrapyrrole with antioxidant properties; very recently, BR has been shown to effectively counteract also nitrosative stress, due to its ability to bind and inactivate NO and RNS [14,17].…”
Section: Resultsmentioning
confidence: 99%
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“…Heme oxygenase-1 (HO-1), also referred to as Hsp32, belongs to the Hsp family and protects brain cells from oxidative stress by degrading toxic heme into free iron, carbon monoxide and biliverdin [17,24]. This latter is then reduced by biliverdin reductase (BVR) into bilirubin (BR), a linear tetrapyrrole with antioxidant properties; very recently, BR has been shown to effectively counteract also nitrosative stress, due to its ability to bind and inactivate NO and RNS [14,17].…”
Section: Resultsmentioning
confidence: 99%
“…This latter is then reduced by biliverdin reductase (BVR) into bilirubin (BR), a linear tetrapyrrole with antioxidant properties; very recently, BR has been shown to effectively counteract also nitrosative stress, due to its ability to bind and inactivate NO and RNS [14,17]. The constitutive isoform of heme oxygenase is HO-2 [28,29].…”
Section: Resultsmentioning
confidence: 99%
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“…37 IL12 is known to be an activator of nitric oxide synthase (NOS), which is important for CNS nitric oxide modulation and synaptic plasticity. 38 In the Stat4 knockout mouse, NOS1 protein expression levels were significantly increased. In this study, STAT4 was differentially expressed and the role of dysregulated STAT4/IL12/NOS in the 15q13.3 deletion phenotypes is of great interest.…”
Section: Discussionmentioning
confidence: 99%
“…FMRP was found to be a positive regulator of NOS1 translation, controlling NOS1 protein levels in a dose-dependent manner in vitro and in vivo (74), and the NOS1 was severely reduced in the fetal and post-natal developing neocortex of FXS patients (74). The evidence of the multiple roles of nitric oxide (NO) in multiple neural processes such as synaptic developmental, retrograde signaling and synaptic plasticity (75)(76)(77)(78)(79) led to the hypothesis that the decrease expression of NOS1 and secondary depletion of NO in the developing FXS brain may contribute to the neuropathology of FXS (80).…”
Section: Neurobiologymentioning
confidence: 99%