2007
DOI: 10.1038/nm1593
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Abstract: The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, and to exploit these molecules for therapeutic purposes. New insights into the pathophysiology of diseases have also enabled us to understand molecular defects in a way that was not possible a dec… Show more

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Cited by 886 publications
(784 citation statements)
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References 122 publications
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“…Differentiated and mineralized MSC at bone‐resorptive sites contribute to new bone formation during bone remodeling 15. Of note, in human, Zn 2+ and Ca 2+ concentrations were also correlated with osteopenia due to estrogen deficiency or aging 16.…”
Section: Resultsmentioning
confidence: 99%
“…Differentiated and mineralized MSC at bone‐resorptive sites contribute to new bone formation during bone remodeling 15. Of note, in human, Zn 2+ and Ca 2+ concentrations were also correlated with osteopenia due to estrogen deficiency or aging 16.…”
Section: Resultsmentioning
confidence: 99%
“…The numerous regulatory mechanisms involved in the control of bone remodeling have been reviewed elsewhere and are beyond the scope of this report. 25 Bariatric Surgery Figure 1. Schema of mechanisms of bone loss after bariatric surgery.…”
Section: Bone Remodeling and Its Relationship To Bone Mineral Densitymentioning
confidence: 99%
“…In contrast, most of the literature agrees that osteoclasts and their precursor cells lack high-affinity PTH receptors. (3,(6)(7)(8) Therefore, it has been proposed that the effects of PTH on osteoclasts are indirect. (9) The PTH receptor on target cells is activated by the binding of PTH or PTHrP.…”
Section: Introductionmentioning
confidence: 99%