Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial

Mellberg, Caroline; Sandberg, Susanne; Ryberg, Mats; Eriksson, Marie; Brage, Sören; Larsson, Christel; Olsson, Tommy; Lindahl, Bernt

doi:10.1038/ejcn.2013.290

Cited by 161 publications

(198 citation statements)

References 33 publications

(30 reference statements)

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“…It was also suggested that a return to an evolutionary adapted diet may be beneficial for health [5]. The paleolithic diet has previously been shown to confer metabolic benefits in healthy as well as in patients with metabolic syndrome [6][7][8][9][10]. Voegtlin, first proponent of the human evolutionary diet, suggested an animal fat-meat based diet as being evolutionary adapted [11].…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet

Tth¹,

Clemens²

2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. IJCRI publishes SUMMARYMetabolic syndrome is made up of a cluster of conditions including obesity, impaired insulin sensitivity, hypertension and altered lipid profile. These conditions are also considered as risk factors for type 2 diabetes and cardiovascular disease. Occurrence of these conditions is on the rise worldwide despite of the increasing number of drugs used. There is evidence from the literature indicating that intervention with low carbohydrate diets, including the paleolithic diet, may be beneficial in the metabolic syndrome. Except for one study with the paleolithic diet these investigations are short in duration. Another limitation is that they do not give clues how to deal with medications patients are treated with. Third, in these studies the paleolithic diet did not produce ketosis which may limit the clinical effectiveness. Here we present a case of a patient with metabolic syndrome and excessively medicated. The patient shifted toward the paleolithic ketogenic diet and was able to discontinue medication, lost weight and her glucose parameters markedly improved. Her hypertension normalized. Currently she is on the diet for 22 months and show good adherence as also confirmed by laboratory tests. She is free of symptoms and no side-effects emerged. Previously we reported cases with epilepsy and type 1 diabetes successfully treated with the same diet. We suggest that a dietary intervention with the paleolithic ketogenic diet may be a simple, feasible and cost-effective method in some forms of chronic disorders in highly motivated patients.(This page in not part of the published article.)

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Section: Introductionmentioning

confidence: 99%

Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet

Tth¹,

Clemens²

2015

IJCRI

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“…By definition, the paleolithic diet excludes foods that were not available in prehistoric times [11,14]. However, the paleolithic diet as published in clinical studies [15,16,17,18] differ from the diet we refer to as paleolithic ketogenic in important aspects including macronutrient ratios and the ratio of animal vs. plant based food components. Moreover, given the availability of internet-based, mainly non-scientific resources, several variants of the paleolithic diet abound which we collectively denote as popular paleolithic diet.…”

Section: Discussionmentioning

confidence: 99%

“…She did not consume offal on a regular basis. This version of the paleolithic diet conforms neither to the paleolithic diet as originally described by Cordain [11] or Lindeberg [14] nor any of those versions in previously published clinical studies of the paleolithic diet [15,16,17,18]. We therefore refer to this diet as a 'popular paleolithic diet' because it appears to arise from a mixture of scientific and unscientific information, much of which is probably gleaned from dubious sources on the internet.…”

Section: The Popular Paleolithic Dietmentioning

confidence: 99%

Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report

Tóth¹,

Schimmer²

2018

JCRT

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Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. To date, only a few case studies reporting long term benefits associated with such diets have been published. Case report: Here we present a case where recurrent cervical intraepithelial neoplasia (CIN), a premalignant condition of cervical cancer, was successfully treated with the paleolithic ketogenic diet. The patient had a history of high grade CIN in 2011, which was successfully treated with cervical conization and fractional curettage. In October 2015 she was found to have a recurrence of high grade CIN (HSIL: High Grade Squamous Intraepithelial Lesion). The patient was then commenced on the paleolithic ketogenic diet and her repeat Pap (Papanicolaou) smear three months later was found to have reverted to normal. The patient has remained on the paleolithic ketogenic diet for 26 months, her repeat smears have stayed normal, and she is free of symptoms and side effects. Conclusion: We conclude that the diet was effective and safe in this patient. As a major benefit the patient was able to avoid a hysterectomy, which is the standard treatment for recurrent high-grade CIN. We believe that the paleolithic ketogenic diet combines benefits of both paleolithic and classical ketogenic diets, while excluding their disadvantages.

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“…a Paleolithic-type diet (PD), or a prudent control diet in concordance with the Nordic Nutrition Recommendations (NNR) for two years. In this secondary analysis, we have used the data from the 6-months follow up, where a consistent response to the diet interventions was found [16][17] .…”

Section: Metabolomics Data -Diet Interventionmentioning

confidence: 99%

Statistical loadings and latent significance simplify and improve interpretation of multivariate projection models

Jonsson

Björkblom

Chorell

et al. 2018

Preprint

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Multivariate projection methods are unique in being both multivariable by combining many variables into stronger predictive features (latent variables), and multivariate for being able to model systematic variation both related and orthogonal to an observed response. Orthogonal partial least squares (OPLS) is a versatile multivariate projection method for analysis of correlation, discrimination and effect changes. However, currently OPLS is not fully using its multivariate potential since orthogonal systematic variation is not considered in model interpretation, resulting in univariate interpretation of variable significance. We present a strategy for improved interpretation of OPLS models based upon a post-hoc linear regression analysis that can be used with or without the orthogonal OPLS score(s) as a covariate to make the interpretation multivariate or univariate respectively. By selecting the observed response y or estimated response yhat as a one of the factors in the linear regression the results are related to either of the OPLS loadings w or p. Furthermore, converting the OPLS loading values to statistical t-values creates a direct link to statistical significance. Finally, by applying three different Boolean loadings W, P and W∧P variable significance can be summarized based on three criteria. W and P reveal if the values in w or p respectively are outside the statistical limits with W∧P being the logical conjunction of W and P (significant if outside limits in both W and P). Two examples are used to verify the proposed strategy. First, a synthetic example, simulating a mix of mass spectra, and second a clinical metabolomics study of a dietary intervention. In the simulated example we show that multivariate interpretation gives higher accuracy for estimation of true differences, mainly due to higher true positive rate. Furthermore, we highlight how application of W∧P for summarizing variable significance leads to higher accuracy. For the metabolomics example, we show that a more detailed interpretation, i.e. larger number of significant metabolites of relevance, is obtained using the multivariate interpretation. In summary, the suggested strategy provides means for facilitated interpretation of OPLS models, beyond univariate statistics, and offers a multivariate tool for discovery of biomarker patterns, i.e. latent biomarkers.. CC-BY-NC-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

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Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial

Cited by 161 publications

References 33 publications

Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet

Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet

Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report

Statistical loadings and latent significance simplify and improve interpretation of multivariate projection models

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