volume 28, issue 5, P686-694 2014
DOI: 10.1038/modpathol.2014.156
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Has erratum 2015-12-30
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Michelle D Reid, Pelin Bagci, Nobuyuki Ohike, Burcu Saka, Ipek Erbarut Seven, Nevra Dursun, Serdar Balci, Hasan Gucer, Kee-Taek Jang, Takuma Tajiri, Olca Basturk, So Yeon Kong, Michael Goodman, Gizem Akkas et al.

Abstract: Ki67 index is now an essential part of classification of pancreatic neuroendocrine tumors. However, its adaptation into daily practice has been fraught with challenges related to counting methodology. In this study, three reviewers used four counting methodologies to calculate Ki67 index in 68 well-differentiated pancreatic neuroendocrine tumors: (1) ‘eye-ball’ estimation, which has been advocated as reliable and is widely used; (2) automated counting by image analyzer; (3) manual eye-counting (eye under a mi…

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