Microarrays—the 21st century divining rod?

He, Yudong; Friend, Stephen H.

doi:10.1038/89022

Cited by 48 publications

(23 citation statements)

References 9 publications

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“…In cancer profiling, the topic of predictivity has been controversial-receiving comments ranging from praise as the histopathology of the 21st century to critical comparisons with pure chance (20,33). In a large prospective validation study, the MammaPrint ® gene signature score for time to distant breast cancer metastasis at 5 years had an AUC value of 0.681 (34).…”

Section: Discussionmentioning

confidence: 99%

Prediction of Ischemic Events on the Basis of Transcriptomic and Genomic Profiling in Patients Undergoing Carotid Endarterectomy

Folkersen

Persson

Ekstrand

et al. 2012

Mol Med

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Section: Discussionmentioning

confidence: 99%

Prediction of Ischemic Events on the Basis of Transcriptomic and Genomic Profiling in Patients Undergoing Carotid Endarterectomy

Folkersen

Persson

Ekstrand

et al. 2012

Mol Med

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“…24 The clinical behavior of osteosarcoma may be determined by large numbers of different genes acting in consort. The use of newer technologies, such as microarray analysis, 56 may unravel the relative contribution of these genes and may help understand better the role of Pgp in the regulation of the clinical prognosis of patients with osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

The association of P‐glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma

Pakos

Ioannidis

2003

Cancer

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The nm23‐H1 gene is known as a potential metastasis suppressor gene in various types of carcinomas. However, the role of nm23‐H1 in colorectal carcinoma still remains controversial and the cellular mechanisms by which its protein may modulate the metastatic phenotype are not yet known. We transfected nm23‐H1 cDNA into the human colon cancer cell line, HT‐29, to test the effects and cellular biological mechanism of nm23 protein in colon cancer. We found that nm23‐H1 strongly inhibited the liver metastasis of HT‐29 cells in nude mice and inhibited the epidermal growth factor (EGF)‐induced cell migration in vitro. Furthermore, we clarified the regulation of the myosin light chain (MLC) phosphorylation by nm23‐H1, which has been demonstrated as having potential role in cell migration. © 2003 Wiley‐Liss, Inc.

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“…2a). To identify reliably good and poor prognostic tumours, we used a powerful three-step supervised classi®cation method, similar to those used previously 8,17,18 . In brief, approximately 5,000 genes (signi®cantly regulated in more than 3 tumours out of 78) were selected from the 25,000 genes on the microarray.…”

mentioning

confidence: 99%