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Cited by 329 publications
(275 citation statements)
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“…Although CBT globally correlates with sleep onset latency, it is not the key factor. The best predictor for a short sleep onset latency is vasodilated distal skin regions (Kräuchi et al 1999a;Kräuchi et al 2000). Heat loss initiation via the onset of nocturnal melatonin secretion may be the mechanism underlying the circadian regulation of sleep propensity ("opening the sleep gate", Tzischinsky and Lavie 1994).…”
Section: Thermoregulation and Sleep: A Circadian Mechanismmentioning
confidence: 99%
See 1 more Smart Citation
“…Although CBT globally correlates with sleep onset latency, it is not the key factor. The best predictor for a short sleep onset latency is vasodilated distal skin regions (Kräuchi et al 1999a;Kräuchi et al 2000). Heat loss initiation via the onset of nocturnal melatonin secretion may be the mechanism underlying the circadian regulation of sleep propensity ("opening the sleep gate", Tzischinsky and Lavie 1994).…”
Section: Thermoregulation and Sleep: A Circadian Mechanismmentioning
confidence: 99%
“…In contrast, subjective sleepiness did not increase (Kräuchi et al 1999b). tures, CBT or its rate of change, heart rate, melatonin onset, and subjective sleepiness ratings) a backward stepwise regression analysis revealed the highest correlations of SOL with DPG in the 1.5-h episode before lights out; all the other potential predictor variables were not included in the regression model (Kräuchi et al 1999a(Kräuchi et al , 2000. Therefore, under our controlled experimental conditions it is an increase of distal vasodilation, and hence heat loss, which goes hand in hand with induction of sleepiness, and in turn with reduced sleep onset latency.…”
Section: Thermoregulation and Sleepinessmentioning
confidence: 99%
“…CBT declines when heat loss surpasses heat production in the evening and vice versa in the morning (6,41). There is growing evidence that body heat loss in the evening via increased distal skin temperatures is the crucial thermoregulatory function for induction of sleepiness and sleep (26,38). The best indirect marker of this readiness for sleep may be the distal-proximal skin temperature gradient (DPG), a measure that has been externally validated to distal skin blood flow (58).…”
mentioning
confidence: 99%
“…The best indirect marker of this readiness for sleep may be the distal-proximal skin temperature gradient (DPG), a measure that has been externally validated to distal skin blood flow (58). The rise of DPG ϳ90 min before lights off is a good predictor for a rapid onset of sleep (38). Because the circadian regulation of CBT is intimately coupled with the circadian regulation of sleepiness and sleep induction (12), the phase relationships (phase of entrainment) between endogenous circadian rhythmicity of the thermoregulatory system and the sleep-wake cycle are important for good sleep.…”
mentioning
confidence: 99%
“…However, the oral administration of ELE seems to cause the activation of parasympathetic nervous system [31]. Parasympathetic nervous system induces the relaxation of the peripheral vascular system, which induces heat emission, resulting to sleep-onset time and sleepiness [39]. Thus, the relaxation of the peripheral vascular system might partially contribute to the hypnotic effect of the orally administered ELE.…”
Section: Discussionmentioning
confidence: 99%