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Cited by 402 publications
(279 citation statements)
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“…The first evidence for a role in transcription came from studies in yeast in which the fusion of the COOH-terminal domain of BRCA1 to a Gal4 DNA binding domain resulted in the activation of a Gal4 reporter construct. This activation was abrogated on the introduction of diseaserelated mutations in the COOH-terminal domain as well as the deletion of the last 11 amino acids of BRCA1 (6)(7)(8). These results were supported by the observation that the BRCA1 COOHterminal domain was highly acidic, a common feature of transcription factors (9).…”
Section: Introductionsupporting
confidence: 75%
“…The first evidence for a role in transcription came from studies in yeast in which the fusion of the COOH-terminal domain of BRCA1 to a Gal4 DNA binding domain resulted in the activation of a Gal4 reporter construct. This activation was abrogated on the introduction of diseaserelated mutations in the COOH-terminal domain as well as the deletion of the last 11 amino acids of BRCA1 (6)(7)(8). These results were supported by the observation that the BRCA1 COOHterminal domain was highly acidic, a common feature of transcription factors (9).…”
Section: Introductionsupporting
confidence: 75%
“…A second clue to the function of BRCA1 is that the C-terminal region contains an acidic domain that can function as a transcriptional activation domain (TAD) in yeast and mammalian cells, when linked to a DNAbinding domain (Gal4) (Chapman and Verma, 1996;Monteiro et al, 1996). TAD function requires the last 300 or so amino acids (aa 1,560-1,863) for maximal activity.…”
Section: Brca1 Proteinmentioning
confidence: 99%
“…A role in transcription was suggested by the finding that BRCA1 has a conserved acidic domain with transcriptional activity in yeast and mammalian cells (Chapman and Verma, 1996;Monteiro et al, 1996). Subsequently, it was found that BRCA1 regulates a variety of transcriptional pathways.…”
Section: Regulation Of Transcriptionmentioning
confidence: 99%
“…Its nuclear functions include inhibition of cell growth [1], induction of apoptosis [2], and regulation of the cell cycle [3]; as well as serving as a transcriptional co-activator [4], an E3 ubiquitin ligase [5] and a caretaker in maintaining genomic integrity [6,7]. The known nonnuclear function of BRCA1 is to regulate centrosome duplication [8].…”
Section: Introductionmentioning
confidence: 99%