2000
DOI: 10.1038/35030140
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Abstract: Superoxide dismutases (SOD) are essential enzymes that eliminate superoxide radical (O2-) and thus protect cells from damage induced by free radicals. The active O2- production and low SOD activity in cancer cells may render the malignant cells highly dependent on SOD for survival and sensitive to inhibition of SOD. Here we report that certain oestrogen derivatives selectively kill human leukaemia cells but not normal lymphocytes. Using complementary DNA microarray and biochemical approaches, we identify SOD a… Show more

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Cited by 750 publications
(601 citation statements)
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References 22 publications
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“…Inhibition of SOD-1 by TR could decrease the capacity of endothelial cells to scavenge the increased level of superoxides, resulting in growth arrest, apoptosis, and inhibition of angiogenesis. These data are in good agreement with recent findings demonstrating that another SOD-1 inhibitor (Huang et al, 2000) -2-methoxyoestradiol is also anti-angiogenic (Fotsis et al, 1994). No damage was observed in already established (non-proliferating) blood vessels in the treated animals.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Inhibition of SOD-1 by TR could decrease the capacity of endothelial cells to scavenge the increased level of superoxides, resulting in growth arrest, apoptosis, and inhibition of angiogenesis. These data are in good agreement with recent findings demonstrating that another SOD-1 inhibitor (Huang et al, 2000) -2-methoxyoestradiol is also anti-angiogenic (Fotsis et al, 1994). No damage was observed in already established (non-proliferating) blood vessels in the treated animals.…”
Section: Discussionsupporting
confidence: 93%
“…Since angiogenesis is characterised by proliferating endothelial cells and reoxygenation, we speculated that inhibition of SOD-1 will diminish the ability of endothelial cells to confront the increased level of ROS during angiogenesis, thus, resulting in inhibition of angiogenesis, of tumour development and metastasis. This assumption is consistent with recent findings demonstrating that the anti-angiogenic compound 2-methoxyoestradiol (Fotsis et al, 1994) is a SOD-1 inhibitor (Huang et al, 2000).…”
supporting
confidence: 93%
“…A mitochondria-dependent mechanism was demonstrated in leukemia, pancreatic carcinoma, Ewing sarcoma and multiple myeloma cells. 19,27,37,41 On the other hand, the use of the FIGURE 3 -Effect of 2ME 2 on the microtubular organization in HT168-M1 human melanoma cells. Cells were cultured on coverslips and treated with Taxol (100 nM, 10 min) or 2ME 2 (5 M, 1 hr).…”
Section: Discussionmentioning
confidence: 99%
“…antisense or chemical inhibitors) targeting cyclin E/CDK (Sausville et al, 2000) or SOD activities (Huang et al, 2000) could also be tested as chemosensitising tools to anthracycline treatment in cyclin E-overexpressing tumours.…”
Section: Discussionmentioning
confidence: 99%