1988
DOI: 10.1038/335229a0
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Abstract: T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.

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Cited by 632 publications
(356 citation statements)
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“…H-Y-specific TCR transgenic mice, which do not express TCR-restricting MHC class I H-2D b molecules, did not show positive selection of H-Y-specific CD8 § g hi transgenic TCR § g + cells (Fig. 1C) [18,24,25]. These cells, however, could escape death from neglect via an endogenous rearrangement of TCR § -chain genes (Fig.…”
Section: Selection Of H-y-specific Tcr Transgenic T Cells In Mice Witmentioning
confidence: 93%
See 1 more Smart Citation
“…H-Y-specific TCR transgenic mice, which do not express TCR-restricting MHC class I H-2D b molecules, did not show positive selection of H-Y-specific CD8 § g hi transgenic TCR § g + cells (Fig. 1C) [18,24,25]. These cells, however, could escape death from neglect via an endogenous rearrangement of TCR § -chain genes (Fig.…”
Section: Selection Of H-y-specific Tcr Transgenic T Cells In Mice Witmentioning
confidence: 93%
“…These cells, however, could escape death from neglect via an endogenous rearrangement of TCR § -chain genes (Fig. 1C, and see also below) [18,24,25]. CD8 § g lo transgenic TCR § g + cells were absent in both H-Y-specific TCR transgenic females and in TCR transgenic mice with a non-selecting H-2 haplotype (Fig.…”
Section: Selection Of H-y-specific Tcr Transgenic T Cells In Mice Witmentioning
confidence: 96%
“…They originate from a large cohort of double-positive (DP) precursor cells (CD4 + CD8 + DP) in the thymus through a highly ordered developmental process called positive selection, during which engagement of TCR on DP cells by self-peptide MHC complex (pMHC) from thymic epithelial cells with appropriate avidity will deliver signals to DP cells and enable these cells to proceed into CD4 or CD8 single-positive (SP) thymocytes (1)(2)(3)(4). Most DP cells die either because of too strong (during negative selection) or too weak interaction (during death by neglect) between their TCR and pMHC (5).…”
mentioning
confidence: 99%
“…To assess the role of CD28 in both positive and negative thymic selection, we utilized the H-Y-specific TCR-Tg mice in which positive selection occurs in females and negative selection occurs in males (that express the male antigen H-Y) [18]. We bred H-Y-specific TCR-Tg RAG-2-deficient (H-Yrag) mice to be deficient in either CD28 (H-Yrag CD28KO) or in both B7.1 and B7.2 (H-Yrag B7DKO) and analyzed the effect of these deficiencies on negative selection in the thymi of H-Yrag males (Fig.…”
Section: Resultsmentioning
confidence: 99%