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Cited by 64 publications
(36 citation statements)
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“…Once many patients had been typed for their transplantation antigens it became apparent that several disease susceptibilities were somehow linked to the transplantation antigen types. It was revealed in studies by B. Benacerraf [21], and later in great and critical detail by H. McDevitt and coworkers [22,23] and by F. Lilly [24], that inbred strains of guinea pigs and mice differed in their responses to some of the model antigens or tumours studied. Because of the availability of well-defined inbred strains of mice, this was readily mapped to the MHC and even to subregions of the MHC in mice by H. McDevitt et al [25].…”
Section: Interpretations Of the Datamentioning
confidence: 99%
“…Once many patients had been typed for their transplantation antigens it became apparent that several disease susceptibilities were somehow linked to the transplantation antigen types. It was revealed in studies by B. Benacerraf [21], and later in great and critical detail by H. McDevitt and coworkers [22,23] and by F. Lilly [24], that inbred strains of guinea pigs and mice differed in their responses to some of the model antigens or tumours studied. Because of the availability of well-defined inbred strains of mice, this was readily mapped to the MHC and even to subregions of the MHC in mice by H. McDevitt et al [25].…”
Section: Interpretations Of the Datamentioning
confidence: 99%
“…For instance, anti-hapten responses are generally not affected in this way (11,18,19). The response to immunogenic carrier molecules under unigenic control is accompanied with strong antibody production against any hapten associated with them, illustrating the specific cooperation between thymus-derived cells and antibody-secreting cells with different specificity.…”
Section: Discussionmentioning
confidence: 99%
“…Experiments were initially designed to identify the cells of the immune system in which Ir genes are expressed and the nature of the process they control. H-linked Ir genes were shown to determine both humoral and cellular immune responses (28). A further analysis revealed that the genes control the recognition of the "carrier" molecule as an immunogen (59), a property of T lymphocytes.…”
Section: Function Of Ir Genesmentioning
confidence: 99%
“…However, when synthetic polypeptides with relatively restricted structural heterogeneity were synthtesizcd (27), the appropriate antigens were available to immunologists to study the genetic requirements for immunogenicity. The response of outbred guinea pigs to hapten conjugates of the poly-L-lysine homopolymer (DNP-PLL) was the first specific immune response documented to be under the control of a single dominant autosomal gene (28). We introduced the terms "responders" and "nonresponders" to distinguish animals possessing or not possessing the gene, and the gene responsible was referred to as an immune response or Ir gene.…”
Section: The Discovery Of Immune Response Genesmentioning
confidence: 99%