Ruthenium-Catalyzed Oxidative Synthesis of 2-Pyridones through C–H/N–H Bond Functionalizations

Abstract

An inexpensive ruthenium catalyst enabled oxidative annulations of alkynes by acrylamides with ample scope, which allowed for the preparation of 2-pyridones employing various electron-rich and electron-deficient acrylamides as well as (di)aryl- and (di)alkyl-substituted alkynes.

Ruthenium‐Catalyzed Synthesis of Heterocycles via CH Bond Activation

“…of copper oxidant with good chemo-and regioselectivity (Eq. (7.23)) [30]. Notably, the ruthenium catalysts displayed improved substrate scope as compared to the similar reactions reported with rhodium catalyst.…”

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

“…It was also shown that certain unsymmetrically substituted alkynes 6-91a produce the corresponding pyridones 6-92a in moderate yields as single regioisomers (Scheme 442). 712 …”

Directing group-assisted transition-metal-catalyzed vinylic C-H bond functionalization

“…(6)). In 2011, Hofmann et al [38] developed an improved method for the pyridone synthesis under Ru-catalysis in which asymmetric dialkyl-substituted alkynes could be employed, affording the products with high regioselectivity (Scheme 29, Eq. (7)).…”