As an atomic-thick layer material, graphene has a large specific surface area, a high electron mobility, and a high sensitivity to electronic perturbations from adsorption/desorption of molecules, which are attractive properties from the sensing perspective. Graphene has been widely studied for sensing applications, e.g., in biosensors and gas sensors. On the other hand, although graphene shows promise in miniaturized and high-performance sensors, many challenges still remain for the low-cost and large-scale fabrication of graphene sensors with reliable performance. Recently, vertically-oriented graphene (VG) has emerged as a new type of graphene material, and VG-based nanostructures have been explored to advance the sensing technology due to VG's unique structure and properties. Using VG as the sensing element, VG sensors have been studied for the detection of biomolecules (e.g., proteins, DNA, and bacteria) and gases (e.g., NO 2 , NH 3 , and H 2 ). The VG-based sensors have shown promising features that could be used to address some challenges of current sensing technologies for biomolecule and gas detection, e.g., high cost, low sensitivity/selectivity, and/or being unsuitable for in situ and real-time detection. Due to its vertical orientation and high conductivity, VG has also been used in green corona discharge with low ozone generation, which is another important application of VG in environmental fields. In this chapter, representative VG-based sensors and VG corona discharge are introduced and discussed.Keywords Environmental application · Electronic biosensor · Electrochemical biosensor · Gas sensor · Corona discharge There is a need for simple and reliable sensors suitable for trace detection in a wide spectrum of applications ranging from medical diagnosis, environmental monitoring, industrial, agricultural to lab-on-a-chip. Semiconducting nanomaterials