2006
DOI: 10.1021/ja0645943
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Abstract: We have synthesized a series of MCM-41-type mesoporous silica nanoparticles (MSN). The surface of the MSNs are functionalized with 3-aminopropyl (AP), 3-guanidinopropyl (GP), 3-[N-(2-guanidinoethyl)guanidino]propyl (GEGP), and N-folate-3-aminopropyl (FAP). In contrast to the ζ-potential of −18.4 mV for FITC-MSN, the values of ζ-potential for AP-, GP-, GEGP-, and FAP-functionalized FITC-MSNs in 100 mM PBS buffer (pH 7.4) increased positively from −11.3, −10.6, −4.0, to +4.9 mV, respectively. The uptake efficien… Show more

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Cited by 782 publications
(701 citation statements)
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References 14 publications
(21 reference statements)
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“…26 In this context, very recently, mesoporous silica materials have been used as scaffolds for the adsorption or encapsulation of decontaminant compounds or enzymes in order to prepare materials for environmental nerve gases degradation. 27 Besides, thermal decomposition of organophosphorous derivatives, previously adsorbed into zeolites, has also been reported. 28 Silica nanoparticles impregnated with reactive chemicals have been also prepared and used for the removal of sulfur mustard and the nerve gas simulant diethylchlorophosphate.…”
Section: Hydrolysis Of Dcnp (A Tabun Mimic) Catalysed By Mesoporous Smentioning
confidence: 99%
“…26 In this context, very recently, mesoporous silica materials have been used as scaffolds for the adsorption or encapsulation of decontaminant compounds or enzymes in order to prepare materials for environmental nerve gases degradation. 27 Besides, thermal decomposition of organophosphorous derivatives, previously adsorbed into zeolites, has also been reported. 28 Silica nanoparticles impregnated with reactive chemicals have been also prepared and used for the removal of sulfur mustard and the nerve gas simulant diethylchlorophosphate.…”
Section: Hydrolysis Of Dcnp (A Tabun Mimic) Catalysed By Mesoporous Smentioning
confidence: 99%
“…13 The particle size is small enough (e200 nm) to evade rapid sequestration by phagocytotic cells of the spleen and to allow long blood circulation. 14 As described in the Supporting Information (SI), 4-carboxyphenylboronic acid (0.15 g), N-hydroxysuccinimide (0.10 g), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.2 g) were introduced to AP-MSN (400 mg) in DMSO (20 mL) to yield the boronic acid-functionalized (0.5 mmol g -1 ) MSN material (BA-MSN) (Figure 1b).…”
mentioning
confidence: 99%
“…They have the potential for substantial loading, zero premature release of proteins, and highly efficient cellular uptake [10,28,29]. Finally, MSNs are able to aid in effective endosomal escape due to the pH buffering properties naturally found on silica nanomaterials which destabilizes the endosomal membrane (the proton sponge effect) [15,20,30,31].…”
Section: Mesoporous Silica Nanoparticles: Ideal Candidates For Proteimentioning
confidence: 99%
“…Degradation of the protein-vehicle composite typically occurs here if it is unable to escape from the endolysosomal entrapment. Once it escapes, it travels through the cytoplasm where the proteins are released from the vehicle to interact with its specific target [3,4,[6][7][8][9][10][11]. One type of inorganic nanoparticle that has been successfully applied as a controlled-release drug delivery system for intracellular protein delivery is mesoporous silica nanoparticle (MSN) materials [4,12].…”
mentioning
confidence: 99%