Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy

Álvarez-Pedrerol, Mar; Guxens, Mònica; Ibarluzea, Jesús; Rebagliato, Marisa; Rodriguez, Angela C. Incollingo; Espada, Mercedes; Goñi, Fernando; Basterrechea, Mikel; Sunyer, Jordi

doi:10.1021/es9007273

Cited by 49 publications

(51 citation statements)

References 37 publications

(57 reference statements)

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“…We have previously demonstrated the ubiquity of exposure to OC xeno-oestrogens in the INMA-Granada cohort (54). In this study, prenatal exposure to 17 OC pesticides or the xeno-oestrogenic burden in the placentas were observed to modify the impact of neonatal TSH on neurodevelopment, in agreement with the suspected capacity of OCs to interfere with the thyroid system (20)(21)(22)(23)(24)(25)(26).…”

Section: Discussionsupporting

confidence: 84%

“…To date, epidemiological studies have described associations of early exposure to OC compounds with TH levels (20)(21)(22)(23)(24)(25)(26) and with neurodevelopment impairment (51)(52)(53). However, a consistent influence on thyroid status and neurodevelopment of many OC compounds at environmental background levels has not been established yet.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies indicate that exposure to certain environmental contaminants may also interfere with maternal thyroid status during pregnancy and with thyroid function in newborns (20)(21)(22)(23)(24)(25)(26). Hence, it has been speculated that some of the neurotoxic effects of early exposure to the environmental chemicals may result from thyroid disruption (27,28).…”

Section: Introductionmentioning

confidence: 99%

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Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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Objective: An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development. Design: We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in [2000][2001][2002]. Methods: TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae. Results: Mean newborn TSH was 3.55 mU/l (rangeZ0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)Z2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoring !P20 on span memory (ORZ5.73), whereas children with TSH in the second quartile (2.05-2.95 mU/l) were at lower risk of scoring !P20 on the verbal scale (ORZ0.24). Neonatal TSH status was also associated with general cognitive and executive function outcomes when controlling for prenatal exposure to OCs or placental TEXB. Conclusions: Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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“…Organochlorine compounds are persistent environmental contaminants that were intensively used in the past as pesticides [1,2]. Some of the undesirable consequences of pesticide use include the presence of residues in the soil, water, and air; residues in plant and animal tissues and the presence of residues in food [3].…”

Section: Introductionmentioning

confidence: 99%

“…Organochlorine pesticides (OCP) are associated with many chronic diseases [4]. Many problems have been linked to these endocrine disrupters, such as neurological damage, birth defects, respiratory illness, breast cancer, lowered sperm counts and immune system dysfunction [1,5].…”

Section: Introductionmentioning

confidence: 99%

The development and optimization of a modified single-drop microextraction method for organochlorine pesticides determination by gas chromatography-tandem mass spectrometry

et al. 2012

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We have developed a new method for single-drop microextraction (SDME) for the preconcentration of organochlorine pesticides (OCP) from complex matrices. It is based on the use of a silicone ring at the tip of the syringe. A 5 μL drop of n-hexane is applied to an aqueous extract containing the OCP and found to be adequate to preconcentrate the OCPs prior to analysis by GC in combination with tandem mass spectrometry. Fourteen OCP were determined using this technique in combination with programmable temperature vaporization. It is shown to have many advantages over traditional split/splitless injection. The effects of kind of organic solvent, exposure time, agitation and organic drop volume were optimized. Relative recoveries range from 59 to 117 %, with repeatabilities of <15 % (coefficient of variation) were achieved. The limits of detection range from 0.002 to 0.150 μg kg −1 . The method was applied to the preconcentration of OCPs in fresh strawberry, strawberry jam, and soil.

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Association of Maternal Exposure to Persistent Organic Pollutants in Early Pregnancy With Fetal Growth

et al. 2020

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Prenatal exposure to persistent organic pollutants (POPs) has been associated with birth size, but data on fetal growth and among racially/ethnically diverse pregnant women remain scarce.OBJECTIVES To assess the association between maternal plasma POPs in early pregnancy and fetal growth and by infant sex and maternal race/ethnicity. DESIGN, SETTING, AND PARTICIPANTSThis cohort study used the National Institute of Child Health and Human Development Fetal Growth Studies-Singleton cohort, which recruited nonobese, low-risk pregnant women before 14 weeks' gestation between July 1, 2009, and January 31, 2013, in 12 community-based clinics throughout the United States. Participants self-identified their race/ethnicity, self-reported their behavioral risk factors, and were followed up throughout their pregnancy. Data were analyzed from July 31, 2018, to June 3, 2019.EXPOSURES Levels of 76 POPs in early gestation plasma were measured: 11 perfluoroalkyl and polyfluoroalkyl substances, 1 polybrominated biphenyl, 9 polybrominated diphenyl ethers (PBDEs), 44 polychlorinated biphenyls (PCBs), and 11 organochlorine pesticides (OCPs). The bayesian kernel machine regression method was used to examine chemical class mixtures, and generalized additive mixed model was used to analyze individual chemicals. MAIN OUTCOMES AND MEASURESFourteen fetal biometrics were measured, including head circumference, abdominal circumference, and femur length, within 5 ultrasonography appointments.RESULTS A total of 2284 low-risk pregnant women were included: 606 women (26.5%) self-identified as white with a mean (SD) age of 30.3 (4.4) years, 589 (25.8%) as black with a mean (SD) age of 25.5 (5.5) years, 635 (27.8%) as Hispanic with a mean (SD) age of 27.1 (5.5) years, and 454 (19.9%) as Asian with a mean (SD) age of 30.5 (4.5) years. A comparison between the 75th and 25th percentile of exposure revealed that the OCP mixture was negatively associated with most fetal growth measures, with a reduction of 4.7 mm (95% CI, −6.7 to −2.8 mm) in head circumference, 3.5 mm (95% CI, −4.7 to −2.2 mm) in abdominal circumference, and 0.6 mm (95% CI, −1.1 to −0.2 mm) in femur length. Higher exposure to the PBDE mixture was associated with reduced abdominal circumference (-2.4 mm; 95% CI, −4.0 to −0.5 mm) and femur length (−0.5 mm; 95% CI, −1.0 to −0.1 mm), and the dioxin-like PCB mixture was associated with reduced head circumference (-6.4 mm; 95% CI, −8.4 to −4.3 mm) and abdominal circumference (-2.4 mm; 95% CI, −3.9 to −0.8 mm). Associations with individual chemicals were less consistent. There were some interactions by fetal sex, although most of the results did not vary by maternal race/ethnicity. For example, oxychlordane (-0.98 mm; 95% CI, -1.60 to -0.36 mm; P for interaction <.001), trans-nonachlor (-0.31 mm; 95% CI, -0.54 to -0.08 mm; P for interaction = .005), and p,p'-dichlorodiphenyldichloroethylene (-0.19 mm; 95% CI, -0.22 to -0.09 mm; P for interaction = .006) were associated with shorter femur length among boys only.CONCLUSIONS AND RELEVANCE This s...

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Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy

Cited by 49 publications

References 37 publications

Newborn TSH concentration and its association with cognitive development in healthy boys

Newborn TSH concentration and its association with cognitive development in healthy boys

The development and optimization of a modified single-drop microextraction method for organochlorine pesticides determination by gas chromatography-tandem mass spectrometry

Association of Maternal Exposure to Persistent Organic Pollutants in Early Pregnancy With Fetal Growth

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