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Cited by 253 publications
(246 citation statements)
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References 143 publications
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“…These reactions comprise the first two steps in the biosynthesis of prostaglandins (PGs), which play a role in a broad range of physiological and pathophysiological processes (1,2). The COX enzymes are the primary targets of the pharmacologic action of the widely used nonsteroidal antiinflammatory drugs (e.g., aspirin, ibuprofen, and naproxen).…”
mentioning
confidence: 99%
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“…These reactions comprise the first two steps in the biosynthesis of prostaglandins (PGs), which play a role in a broad range of physiological and pathophysiological processes (1,2). The COX enzymes are the primary targets of the pharmacologic action of the widely used nonsteroidal antiinflammatory drugs (e.g., aspirin, ibuprofen, and naproxen).…”
mentioning
confidence: 99%
“…COX-1 is constitutively expressed in most tissues, whereas COX-2 is highly inducible in response to inflammatory and mitogenic stimuli. Thus, it is generally accepted that the primary factor that differentiates the two isoforms is their distinct patterns of expression (1).…”
mentioning
confidence: 99%
“…2-AG is an endocannabinoid, and it classically exerts its effects through activation of the cannabinoid receptors, CB 1 and CB 2 . However, it also is a known substrate for the COX and lipoxygenase enzymes (19,21,38). Some of the effects of 2-AG have been shown to be mediated by some of its metabolites, such as arachidonic acid and its PG derivatives, or through the action of 2-AG on the PPARs (10,19,(39)(40)(41).…”
Section: Discussionmentioning
confidence: 99%
“…Classically, 2-AG binds to and activates two G-protein-coupled receptors, termed cannabinoid receptors 1 and 2 (CB 1 and CB 2 ); however, it may also activate the peroxisome proliferator-activated receptors (PPARs) (20). Alternatively, this endogenous lipid, like arachidonic acid, may also be oxidized by cyclooxygenase (COX) enzymes to produce prostaglandin glycerol esters (PG-Gs) (21). So far, the biological effects of these PG-Gs are not fully elucidated.…”
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confidence: 99%
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