2020
DOI: 10.1021/acs.jpcb.0c08089
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Abstract: Nanoparticle (NP)-mediated therapies are promising tools for the treatment of a wide range of diseases, including stroke and cancer, due to the outstanding performance they have shown for specifically targeting diseased sites. Importantly, the coupling of stiffness and shape of NPs has a significant influence on transportation via blood flow and internalization by targeted cells. Nevertheless, the underlying mechanism of this coupling effect on the endocytosis of NPs remains largely unexplored, resulting from … Show more

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Cited by 15 publications
(7 citation statements)
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“…Compared to spherical particles, mechanical properties of nonspherical soft particulates have been much less investigated and mainly include those where particle geometry and stiffness are varied independently. , There are much fewer studies on the comparative impact of nonspherical shape in which particle shape is systematically varied while composition and size remain the same. The main challenges in the fabrication of soft colloids with complex geometries and monodisperse size are the synthetic difficulties of scale-up.…”
Section: Effect Of Particle Shapementioning
confidence: 99%
“…Compared to spherical particles, mechanical properties of nonspherical soft particulates have been much less investigated and mainly include those where particle geometry and stiffness are varied independently. , There are much fewer studies on the comparative impact of nonspherical shape in which particle shape is systematically varied while composition and size remain the same. The main challenges in the fabrication of soft colloids with complex geometries and monodisperse size are the synthetic difficulties of scale-up.…”
Section: Effect Of Particle Shapementioning
confidence: 99%
“…In previous work, numerous results have indicated that the physicochemical properties of NPs 12 such as size, [13][14][15][16][17][18] shape, [19][20][21][22][23][24][25] stiffness [26][27][28][29][30] and surface property [31][32][33][34] can affect their internalization pathway and efficiency. In particular, experimental studies demonstrated that CME is size-dependent internalization of NPs.…”
Section: Introductionmentioning
confidence: 99%
“…Receptor-mediated endocytosis is a primary route exploited in drug delivery to deliver the NPs and drug molecules into tumor cells [16,17]. In general, receptor-ligand complexes form when mobile receptors on the cell membrane diffuse to bind ligands on the NP's surface.…”
Section: Introductionmentioning
confidence: 99%
“…Accumulating evidence indicates that NP uptake through receptor-mediated endocytosis depends strongly on their physical and chemical characteristics, including the size, shape, stiffness, and surface functionality [17,[29][30][31][32]. For instance, it has been well recognized that there is an optimal size of NP during the endocytosis process, at which the cellular uptake reaches a maximum in a cell type-dependent manner [33][34][35].…”
Section: Introductionmentioning
confidence: 99%