Antifouling Coatings via Tethering of Hyperbranched Polyglycerols on Biomimetic Anchors

Pranantyo, Dicky; Xu, Liqun; Neoh, K. G.; Kang, En‐Tang; Teo, Serena Lay‐Ming

doi:10.1021/acs.iecr.5b03735

Cited by 42 publications

(44 citation statements)

References 55 publications

(98 reference statements)

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“…After 36 h incubation, precipitation was observed in the culture solution. The protein adsorption phenomenon of PDA coating was also observed and investigated by many researchers [ 25 , 40 ]. Lots of research results showed the adsorption behavior might arise from the adhesive nature of PDA coating and the attraction between the possible π–π stacking of the PDA layer and protein molecules [ 25 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…The protein adsorption phenomenon of PDA coating was also observed and investigated by many researchers [ 25 , 40 ]. Lots of research results showed the adsorption behavior might arise from the adhesive nature of PDA coating and the attraction between the possible π–π stacking of the PDA layer and protein molecules [ 25 , 40 ]. As expected, the size of the obtained MSNs@PDA-PSPP nanoparticles nearly kept unchanged not only in PBS solution but also in protein media ( Figure 5 B), indicating few proteins could adsorb on the surface of MSNs@PDA-PSPP due to the excellent anti-protein adsorption ability of the PSPP layer.…”

Section: Resultsmentioning

confidence: 99%

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Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery

et al. 2018

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Multifunctional drug carriers have great applications in biomedical field. In this study, we introduced both polydopamine (PDA) and zwitterionic polymer of poly(3-(3-methacrylamidopropyl-(dimethyl)-ammonio)propane-1-sulfonate) (PSPP) onto the surface of mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle (MSNs@PDA-PSPP), which was employed as a new kind of drug carrier for the delivery of doxorubicin (DOX). The PDA coating, as a gatekeeper, could endow the drug carrier with pH-sensitive drug release performance. The outermost PSPP layer would make the drug carrier possess protein resistance performance. The chemical structure and properties were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA). MSNs@PDA-PSPP could keep good colloidal stability within 72 h in phosphate buffered saline (PBS) and protein solutions. Meanwhile, MSNs@PDA-PSPP exhibited a high drug loading for DOX. In vitro drug release experiments suggested MSNs-DOX@PDA-PSPP exhibited pH-dependent drug release behaviors. Besides, MSNs@PDA-PSPP had no cytotoxicity to human hepatocellular carcinoma cells (HepG2 cells) even at a concentration of 125 µg/mL. More importantly, cellular uptake and in vitro anticancer activity tests suggested that MSNs-DOX@PDA-PSPP could be taken up by HepG2 cells and DOX could be successfully released and delivered into the cell nuclei. Taken together, MSNs@PDA-PSPP have great potential in the biomedical field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery

et al. 2018

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“…Ji and coworkers demonstrated that PDA nanolayer coating was ultrastable and biocompatible for gold nanoparticles in vivo . Kang and coworkers developed various mussel‐inspired catechol‐functionalized polymers with excellent antifouling properties . Encouraged by these advantageous performances, it is feasible to use mussel‐inspired approach to fabricate effective anti‐infective coatings.…”

Section: Methodsmentioning

confidence: 99%

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Feng

et al. 2019

Macromol. Rapid Commun.

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In this work, a novel biomimetic surface‐attachable initiator is successfully synthesized by the conjugation of 3,4‐dihydroxyphenylacetic acid and thermal 2,2′‐azobis(2‐methylpropionamide) dihydrochloride (V‐50). The synthesized initiator (DOPV) can adhere to various material surfaces in a mussel‐inspired way and initiate the surface grafting polymerization. Hydrogel coatings are facilely prepared by the thermal‐initiated radical copolymerization of antimicrobial polyhexamethylene guanidine and antifouling polyethylene glycol oligomers. The developed hydrogel coatings not only show antimicrobial activity toward gram‐negative and gram‐positive bacteria but also demonstrate protein resistance, antibiofilm efficacy, hemocompatibility, and low cytotoxicity in vitro. Most importantly, the hydrogel coatings reveal excellent antimicrobial efficacy with a log reduction above 5 in a rodent subcutaneous infection model. These results demonstrate the potential fabrication of bio‐functional coatings for biomedical devices or implants through an inexpensive, facile, and environmentally friendly mussel‐inspired technique.

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“…Poligliserol banyak cabang (Hyperbranched polyglycerol/ HPG) merupakan poligliserol dengan struktur unik, kaya gugus hidroksi (Wilms, Stiriba, dan Frey 2010) dan dapat diaplikasikan di berbagai bidang seperti sebagai penyangga katalis (Nasseri, Ali dan Sadeghzadeh 2013), pengantar obat (Boudou et al 2013), dan pelapisan (Pranantyo et al 2016). Pada umumnya poligliserol disintesis dari glisidol melalui proses pembukaan cincin (ring-opening) polimerisasi (Kainthan et al 2006).…”

Section: Pendahuluanunclassified

Karakteristik Mineral Lokal sebagai Katalis Pada Sintesis Poligliserol Banyak Cabang (Hyperbranched Polyglycerol)

et al. 2017

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ABSTRAK KARAKTERISTIK MINERAL LOKAL SEBAGAI KATALIS PADA SINTESIS POLIGLISEROL BANYAK CABANG (HYPERBRANCHED POLYGLYCEROL).Poligliserol banyak cabang (Hyperbranched Polyglycerol /HPG) mempunyai struktur unik dan kaya gugus hidroksi sehingga berpotensi untuk diaplikasikan di berbagai bidang. Dalam pembuatan HPG, katalis mempunyai peranan penting dalam pembentukan strukturnya. Mineral dalam bentuk oksida sudah umum digunakan sebagai katalis pada proses kimia. Penelitian ini bertujuan untuk menggunakan mineral lokal yaitu kapur tohor dan dolomit sebagai katalis pada pembuatan HPG. Batuan kapur dan dolomit dipanaskan terlebih dahulu untuk membentuk CaO dan MgO. Pemanasan batuan kapur pada suhu 900°C sudah menghasilkan CaO dan CaCO3, sedangkan pemanasan dolomit pada suhu 750°C menghasilkan MgO dan CaCO3. Proses polimerisasi dilakukan pada suhu 250°C dan waktu proses 20 jam. Hasilnya menunjukkan bahwa penggunaan kapur tohor sebagai katalis menghasilkan HPG dengan cabang yang lebih banyak dibandingkan jika menggunakan dolomit. Dari spektrum 13 C NMR pada pergeseran kimia 72 ppm sampai dengan 73,5 ppm yang diindikasikan sebagai HPG jenis dendritik mengeluarkan 6 puncak bila menggunakan kapur tohor dan mengeluarkan 1 puncak bila menggunakan dolomit. Spektrum 1 H NMR pada pergeseran kimia 3 ppm sampai dengan 4 ppm yang diindikasikan sebagai CH-O mengeluarkan 4 puncak bila menggunakan kapur tohor ataupun dolomit. Penambahan waktu proses sampai 20 jam pada proses polimerisasi dengan katalis kapur tohor menghasilkan 5 puncak spektrum 1 H NMR. Bertambahnya jumlah puncak menandakan bertambah banyaknya gugus CH-O, selain itu penambahan waktu proses juga menaikkan jumlah gugus fungsi OH yang keluar pada pergeseran kimia 4,4 ppm sampai dengan 4,7 ppm.

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Antifouling Coatings via Tethering of Hyperbranched Polyglycerols on Biomimetic Anchors

Cited by 42 publications

References 55 publications

Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery

Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Karakteristik Mineral Lokal sebagai Katalis Pada Sintesis Poligliserol Banyak Cabang (Hyperbranched Polyglycerol)

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