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Cited by 86 publications
(43 citation statements)
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References 28 publications
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“…A VNTR of 86 bp repeats within intron 2 of the gene was tested for association with bone variables in several studies. Significant association of the VNTR polymorphism with rates of change in spinal bone mass, spine bone loss (Keen et al 1998), and lumbar and hip BMD (Langdahl et al 2000c, Fontova et al 2002 was identified.…”
Section: Other Genetic Polymorphismsmentioning
confidence: 97%
“…A VNTR of 86 bp repeats within intron 2 of the gene was tested for association with bone variables in several studies. Significant association of the VNTR polymorphism with rates of change in spinal bone mass, spine bone loss (Keen et al 1998), and lumbar and hip BMD (Langdahl et al 2000c, Fontova et al 2002 was identified.…”
Section: Other Genetic Polymorphismsmentioning
confidence: 97%
“…Population-based association studies have suggested that genetic effects can be ascribed to polymorphisms of a number of genes involved in bone metabolism, although the genetic basis of osteoporosis is not well understood. Polymorphisms of genes encoding vitamin D receptor (VDR), estrogen receptor (ER), collagen type I alpha (COL1A1), calcitonin receptor (CTR), osteocalcin, transforming growth factor-beta (TGF-beta), interleukin-1 receptor antagonist (IL-1RN), insulin-like growth factor-I (IGF-I), calcitonin receptor (CTR), parathyroid hormone (PTH), peroxisome proliferator-activated receptor gamma (PPAR gamma), calcitonin (CT), and interleukin-6 (IL6) have all been implicated as genetic markers for BMD (Morrison et al 1994;Sano et al 1995;Grant et al 1996;Dohi et al 1998;Keen et al 1998;Masi et al 1998;Miyao et al 1998;Taboulet et al 1998;Yamada et al 1998;Hosoi et al 1999;Ogawa et al 1999;Tsukamoto et al 1999;Miyao et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…(3) The vitamin D receptor (VDR) gene was the first of several candidate genes implicated in the genetic determination of BMD. (4) Other studies on allelic variations of genes such as the estrogen receptor (ER) gene, (5,6) the ER ␤ gene, (7) the interleukin-6 (IL-6) gene, (8) or the IL-1 receptor antagonist (IL-1ra) gene (9) have shown association with BMD and fractures, although conflicting results have been published. (10 -21) Type I collagen is the most abundant protein of bone matrix.…”
mentioning
confidence: 99%