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citations
Cited by 261 publications
(205 citation statements)
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References 54 publications
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“…To bridge the transcriptional machinery to NRs, through the coactivator protein:protein interaction domains of either p300/CBP (Nakajima et al, 1997) or SMCC (Chiba et al, 2000., Malik andRoeder, 2000), in order to recruit the Pol II holoenzyme and its associated TFII factors to promoter region. As for transcriptional corepressors, NCoR-and SMRT-containing complexes, are suggested to antagonize the chromatin modifying activities of coactivators to generate a transcriptionally repressed state within the promoter region (for review see Hu and Lazar, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…To bridge the transcriptional machinery to NRs, through the coactivator protein:protein interaction domains of either p300/CBP (Nakajima et al, 1997) or SMCC (Chiba et al, 2000., Malik andRoeder, 2000), in order to recruit the Pol II holoenzyme and its associated TFII factors to promoter region. As for transcriptional corepressors, NCoR-and SMRT-containing complexes, are suggested to antagonize the chromatin modifying activities of coactivators to generate a transcriptionally repressed state within the promoter region (for review see Hu and Lazar, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…In the absence of T3, the unliganded receptors (aporeceptors) recruit corepressors and repress the transcription of target genes. Upon hormone binding, the receptors (holoreceptors) exchange corepressors for coactivators and activate transcription (2). This repressive effect of aporeceptors has been clearly documented in hypothyroid mice for TR␣ in brain, bone, intestine, spleen, and heart (3,4).…”
mentioning
confidence: 99%
“…They possess histone deacetylase activity, which can inhibit the basal transcriptional machinery and the assembly of preinitiation complexes [10,[16][17][18]. In contrast to coactivators, comparatively little is known of the actions of specific corepressors, and a definition of their involvement in transcriptional repression is still emerging.…”
Section: Nuclear Receptor Cofactorsmentioning
confidence: 99%