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Cited by 335 publications
(295 citation statements)
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References 48 publications
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“…Protein Tyr phosphatases are important signaling enzymes that regulate protein phosphorylation events in all eukaryotes (Walton and Dixon, 1993;Fauman and Saper, 1996), particularly the inactivation of MAPK cascades (Luan, 1998). Oxidative stress activates MAPK cascades not only in plants Kovtun et al, 2000), but also in animals (Fialkow et al, 1994;Irani et al, 1997), where Tyr phosphatases have been identified as a primary target for H 2 O 2 (Wu et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Protein Tyr phosphatases are important signaling enzymes that regulate protein phosphorylation events in all eukaryotes (Walton and Dixon, 1993;Fauman and Saper, 1996), particularly the inactivation of MAPK cascades (Luan, 1998). Oxidative stress activates MAPK cascades not only in plants Kovtun et al, 2000), but also in animals (Fialkow et al, 1994;Irani et al, 1997), where Tyr phosphatases have been identified as a primary target for H 2 O 2 (Wu et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Because the active site of PTPs contains a cysteine residue, which is essential in the catalytic process of tyrosine dephosphorylation (Stone and Dixon, 1994;Fauman and Saper, 1996), the PTP family of proteins was considered to be a likely group of target for the action of arylating K vitamin analogs. Since PTPs play an important role in the processes of tyrosine dephosphorylation, their inactivation could cause an imbalance of protein tyrosine phosphorylation and dephosphorylation and perturb the regulation of cell growth and many other cellular functions.…”
Section: Mechanisms Of Cell Growth Inhibition By K Vitamin Analogs Prmentioning
confidence: 99%
“…Tyrosine phosphatases have been shown to be involved in transduction pathways controlling cell growth and differentiation. 5 Myotubularin is highly conserved through evolution and several homologous human genes were found, which define a new family of putative tyrosine phosphatases in man.…”
Section: Introductionmentioning
confidence: 99%