Dopamine-derived endogenous N-methyl-(R)-salsolinol

Naoi, Makoto; Maruyama, Wakako; Akao, Yukihiro; Yi, Hong

doi:10.1016/s0892-0362(02)00211-8

Cited by 100 publications

(50 citation statements)

References 60 publications

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“…This catechol isoquinoline may be synthesized directly from DA and acetaldehyde or indirectly, forming salsolinol-1-carboxylic acid and further to salsolinol (Naoi et al 1996(Naoi et al , 2002. Although not all enzymes of an indirect pathway of salsolinol synthesis are known, this compound and its metabolites can be detected in many areas of the brain that are also rich in DA (Toth et al 2001, Naoi et al 2002.…”

Section: Discussionmentioning

confidence: 99%

“…As reported by Naoi et al (1996Naoi et al ( , 2002, salsolinol can be synthesized from dopamine (DA) and acetaldehyde or alternatively, from DA and pyruvic acid by forming an intermediate metabolite, salsolinol-1-carboxylic acid. This DA-originated compound, which is well known from its involvement in the progression of a disease characterized by dysfunctional dopaminergic neurons (Moser et al 1995, Antkiewicz-Michaluk 2002, was found to be present in neuro-intermediate lobe (NIL) as well as median eminence (ME) extracts of male, intact and ovariectomized female rats (Toth et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Misztal

Górski²,

Tomaszewska-Zaremba³

et al. 2008

Journal of Endocrinology

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The push-pull perfusions of the infundibular nucleus-median eminence (IN/ME) were made in lactating ewes (nZ7) twice, to identify dopamine (DA)-derived salsolinol and the changes in its extracellular concentration in response to suckling. The perfusate collecting period in every ewe consisted of control non-suckling period, 1000-1230 h (five perfusates), and suckling period, 1230-1500 h (next five perfusates). Simultaneously, blood samples were collected from 1000 to 1500 h at 10-min intervals. The perfusate concentrations of salsolinol and DA were measured by HPLC, and plasma prolactin and GH concentrations were assayed by the RIA. Mean concentrations of salsolinol in perfusates collected from the anterior and posterior parts of the IN/ME (according to post-mortem localization of a perfusion site) increased significantly (P!0 . 05 and P!0 . 001 respectively) during the suckling period, when compared with those noted during the non-suckling period. While no DA was found in the anterior part, only vestigial amounts of DA were found in a few perfusates collected from the posterior part. Salsolinol was not detected in the IN/ME of ewes 10 weeks after weaning (seasonal anoestrus). Mean plasma prolactin and GH concentrations during suckling were significantly (P!0 . 001) higher than those noted during the non-suckling period. In conclusion, our current study reveals that salsolinol is present in the IN/ME of lactating ewes and that its extracellular concentration increases during suckling. Moreover, it supports the role of salsolinol as a neurotransmitter involved in the regulatory process of prolactin secretion at least during lactation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Misztal

Górski²,

Tomaszewska-Zaremba³

et al. 2008

Journal of Endocrinology

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“…Metabolites and byproducts of SAM, such as N-methyl dopamine, 3,4-dimethoxy-dopamine, N-methylsalsolinol (Maruyama, et al, 1996;Naoi et al, 2002;Matsubara et al, 2002) and harman and norharman (Kuhn, et al, 1996) are elevated in the CSF of PD patients and homocysteine ) may cause PD like toxic changes. In addition, methyl-beta-carboline was reported to cause PD-like changes (Collins, et al 1992; Gearhart et al, 1997).…”

Section: Common Markers Exist For Methylation and Parkinsonismmentioning

confidence: 99%

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

Charlton¹

2013

Basal Ganglia - An Integrative View

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“…dopamine-derived alkaloids, salsolinol and NMSal have been confirmed to have selective neurotoxicity to dopamine neurons [12] . Table 1 …”

Section: Effect Of Fe 2+ On Dopamine-induced Intracellular Salsolinolmentioning

confidence: 99%

Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells

et al. 2008

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Dopamine-derived endogenous N-methyl-(R)-salsolinol

Cited by 100 publications

References 60 publications

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells

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