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Cited by 149 publications
(109 citation statements)
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References 79 publications
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“…NADPH oxidase is a heme-containing membrane enzyme that catalyzes the production of O 2 À from oxygen and NADPH (40). Although NADPH oxidase has been originally identified as a unique enzyme of neutrophils, several NADPH oxidase-like heme-containing enzymes have been identified in non-neutrophil cells (41). Carbon monoxide (CO), which is produced solely by HO activity in mammalian cells, is known to bind and inhibit the heme-containing enzymes including NADPH oxidase (42)(43)(44).…”
Section: Discussionmentioning
confidence: 99%
“…NADPH oxidase is a heme-containing membrane enzyme that catalyzes the production of O 2 À from oxygen and NADPH (40). Although NADPH oxidase has been originally identified as a unique enzyme of neutrophils, several NADPH oxidase-like heme-containing enzymes have been identified in non-neutrophil cells (41). Carbon monoxide (CO), which is produced solely by HO activity in mammalian cells, is known to bind and inhibit the heme-containing enzymes including NADPH oxidase (42)(43)(44).…”
Section: Discussionmentioning
confidence: 99%
“…In the respiratory tract, pulmonary neuroepithelial bodies (NEBs) within the airway mucosa represent specialized pulmonary structures that are composed of clusters of innervated amine-and peptide-containing cells, and are involved in mediating airway responses to hypoxia. Based on studies with NADPH oxidase inhibitors and gp91phox (NOX2)-deficient mice, it has been demonstrated that these responses are due to the presence of NOX2, which acts as an oxygen sensor by regulating O 2 -sensitive K+ currents, via altered production of ROS (4,175). NADPH oxidase (most likely NOX2) has been suggested to play a more universal role as oxygen sensor in various tissues, thereby mediating hypoxic pulmonary vasoconstriction, vascular smooth muscle function, and carotid and airway chemoreceptor activation (4).…”
Section: Functional Aspects Of Nox In Other Lung Cell Typesmentioning
confidence: 99%
“…We now know that a number of NADPH homologs are present in many diverse aerobic organisms, with appear to have evolved by using these enzyme systems for regulated ROS production in various aspects of cell biology. Indeed, recent studies over the past several years have linked NADPH oxidases (NOX's) to cellular processes as diverse as cell proliferation, migration, differentiation, immunomodulation, and oxygen sensing (1)(2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%
“…The reaction was stopped by adding EDTA and heating for 10 min at 65 °C. The first strand cDNA was synthesized by utilizing oligo(dT) [12][13][14][15][16][17][18] primer and the SuperScript II™ reverse transcriptase (Invitrogen) in a 20 μl reaction which contains DTT and dNTP. Three microliters of product was subjected to PCR reaction which included 2 μl gene-specific primer pairs (5 μM) and 45 μl Platinum PCR Supermix (Invitrogen) on an Eppendorf MasterCycler for 35 cycles.…”
Section: Total Rna Isolation Reverse Transcription and Pcr Cloningmentioning
confidence: 99%
“…The novel non-phagocytic Nox/Duox proteins contain highly conserved binding sites for NADPH, FAD and heme. However, their functions are less well known when compared to Nox2 [5,16,17].…”
Section: Introductionmentioning
confidence: 99%