2000
DOI: 10.1016/s0735-1097(99)00533-1
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Abstract: Large eccentric plaque containing an echolucent zone by IVUS can be at increased risk for instability even though the lumen area is preserved at the time of initial study. Compensatory enlargement of vessel wall due to remodeling may contribute to the relatively small degree of stenosis by angiography.

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Cited by 405 publications
(217 citation statements)
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References 27 publications
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“…Initial description of plaque morphology focused on culprit lesions in patients presenting with acute or stable coronary syndromes 93,94 . Based on these studies, a prospective intravascular ultrasound study hypothesized that certain features would be associated with the development of acute coronary syndromes during follow-up 95 . The authors examined morphologic features of vulnerability in mild-tomoderately stenotic plaques at baseline and during 2-year follow-up period.…”
Section: Plaque Composition With Ivusmentioning
confidence: 99%
“…Initial description of plaque morphology focused on culprit lesions in patients presenting with acute or stable coronary syndromes 93,94 . Based on these studies, a prospective intravascular ultrasound study hypothesized that certain features would be associated with the development of acute coronary syndromes during follow-up 95 . The authors examined morphologic features of vulnerability in mild-tomoderately stenotic plaques at baseline and during 2-year follow-up period.…”
Section: Plaque Composition With Ivusmentioning
confidence: 99%
“…Indeed, patients with these plaques may be at higher risk, because major cardiovascular events were reported in the presence of positive VR. 8 The rise in slope of ⌬WT ax /⌬SS ax from negative to zero or positive with AS (loss of lumen preservation) indicates that plaque location is no longer restricted to the average low SS locations. A reason for this is lateral plaque extension (indicated by PFVW decrease) possibly induced by repetitive small ruptures of the plaque and healing at its shoulders.…”
Section: Wentzel Et Al Compensatory Remodeling and Shear Stressmentioning
confidence: 99%
“…7 In addition, acute events occur more frequently in compensatory enlarged arteries. 7,8 This might be a consequence of the prolonged development of unfavorable types of plaques at low SS predilection locations because of SS control, which preserves normal lumen and normal SS distribution, thereby maintaining locations with lessfavorable flow conditions. Studies determining SS control and its relation with vessel remodeling and plaque accumulation in human coronary arteries in vivo have not been performed.…”
mentioning
confidence: 99%
“…Third, previous studies have reported that a coronary artery that has undergone positive remodeling is associated with vulnerability and accompanied by much more lipid-rich plaque. 4 Based on these findings, lipid-rich plaque with a wider lipid arc (eg, groups 3 and 4 in this study) might be often accompanied by larger vessel area with positive remodeling compared with lipid plaque that has a narrower lipid arc (eg, groups 1 and 2 in this study). Therefore, in the current study, mean difference and limits of agreement might increase with the increase in lipid arc, implying less accuracy of circular approximation in lipid-rich plaque with a wider lipid arc.…”
Section: Article P 600mentioning
confidence: 61%
“…studies reported that positive remodeling was detected more frequently in unstable coronary lesions. 4 Furthermore, autopsy studies have shown that positive remodeling is associated with underlying lesions with the histological characteristics of plaque vulnerability, such as a large lipid core and high plaque macrophage content. 5 Under these conditions, OCT is not suitable for assessment of positive remodeling because of its limited penetration depth in a large vessel with plaque containing a large lipid core.…”
Section: Article P 600mentioning
confidence: 99%