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Cited by 578 publications
(276 citation statements)
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References 24 publications
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“…Particles are often formulated using emulsification techniques requiring organic solvents [215] although there are other approaches include gelation of polymers suspended in emulsion droplets when the suspension is exposed to a change in temperature, pH or addition of crosslinking agents [216]. By tailoring polymers and formulation conditions, it is possible to exert control over intrinsic triggers for antigen release (pH, the presence of certain enzymes etc.)…”
Section: Synthetic Particle-based Strategiesmentioning
confidence: 99%
“…Particles are often formulated using emulsification techniques requiring organic solvents [215] although there are other approaches include gelation of polymers suspended in emulsion droplets when the suspension is exposed to a change in temperature, pH or addition of crosslinking agents [216]. By tailoring polymers and formulation conditions, it is possible to exert control over intrinsic triggers for antigen release (pH, the presence of certain enzymes etc.)…”
Section: Synthetic Particle-based Strategiesmentioning
confidence: 99%
“…The drug loading efficiency and encapsulation efficiency was also near 100% similar to the percent yield. De Campos and others have shown chitosan nanoparticles to have an entrapment efficiency of cyclosporine A, a hydrophobic drug like PTX, to be 74% (14). The entrapment efficiency of chitosan is dependant on many factors such as molecular weight of chitosan used, concentration of the drug molecules and pH of the formulation (25).…”
Section: Nanoparticle Characterizationmentioning
confidence: 99%
“…Chitosan has been shown to have bioadhesive properties due to interactions with the mucous membranes associated with epithelial barriers and tumors (12)(13)(14)(15). Almost all human epithelial cell adenocarcinomas, nonepithelial cancer cell lines, hematological malignancies such as multiple myeloma, and some B-cell non-Hodgkin lymphomas exhibit an over expression of mucin-1 (16).…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, the most frequently explored polysaccharide for the design of nanodelivery systems was chitosan, a cationic polymer composed of repeating β-(1,4)-linked N-acetylglucosamine and D-glucosamine units, which is obtained by chitin deacetylation and assumes different molecular weights and deacetylation degrees (Chiellini et al, 2008;Hassani et al, 2012;Mizrahy and Peer, 2012). Apart from the reported biocompatibility and biodegradability (Dornish et al, 1997;Grenha et al, 2010a;Hirano et al, 1988), the most outstanding properties of chitosan rely on its mucoadhesive character (Lehr et al, 1992) and demonstrated ability to potentiate transmucosal absorption both as molecule (Artursson et al, 1994;Borchard et al, 1996;Portero et al, 2002) and in the form of nanoparticle (Al-Qadi et al, 2012;De Campos et al, 2001;Fernández-Urrusuno et al, 1999a;Prego et al, 2005a;Yamamoto et al, 2005).…”
Section: Introductionmentioning
confidence: 99%