Familial comparison of bone mineral density at the proximal femur and lumbar spine

McKay, Heather; Bailey, D. A.; Wilkinson, Alex; Houston, C. Stuart

doi:10.1016/s0169-6009(08)80148-1

Cited by 57 publications

(30 citation statements)

References 26 publications

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“…We observed significant motherdaughter correlations in BMD, consistent with other parent-offspring studies, (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) which did not change substantially with adjustment for potential covariates, such as age and anthropometry. Daughters, particularly premenopausal daughters, of mothers with ''normal BMD'' had greater BMD at all sites than daughters of mothers who had established osteoporosis.…”

Section: Discussionsupporting

confidence: 89%

“…Low bone mass is associated with increased risk of fracture but is considered a necessary, not a sufficient, predisposing factor. (3) Previous studies have reported significant and relatively consistent parent-offspring correlations in bone mineral density (BMD) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and have shown that a family history of osteoporosis and/or fracture is associated with an increased risk of low BMD and fracture. (14)(15)(16)(17)(18)(19) Some, (14,16) but not all, (6,13,(17)(18)(19) of these studies confirmed a family history of osteoporosis or fracture via medical records or radiographs.…”

Section: Introductionmentioning

confidence: 99%

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Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Danielson

Cauley

Baker

et al. 1999

Journal of Bone and Mineral Research

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The familial resemblance in bone mineral density (BMD) and calcaneal broadband ultrasound attenuation (BUA) was examined in 207 mother-daughter pairs. Mothers were participants in the Study of Osteoporotic Fractures. Three groups of daughters were recruited based on their maternal history of ''fracture,'' ''low BMD'' without fracture (< 0.58 g/cm 2 , t-score < −2.5), and ''normal BMD'' without fracture (> 0.67 g/cm 2 , t-score > −1.6). Data on other potentially heritable factors known to influence BMD and BUA were also collected. BMD was measured at the hip, spine, whole body, and calcaneus. Calcaneal BUA was assessed using the Walker-Sonix UBA 575. Total hip and femoral neck BMD were significantly lower (5.0-8.0%, p < 0.017) among daughters, in particular premenopausal daughters, of mothers with established osteoporosis (''fracture'' or ''low BMD'') compared with daughters of mothers at lower risk of osteoporosis (''normal BMD''). BUA did not differ across daughter groups. Lifestyle characteristics (dietary calcium, smoking, physical activity) were not highly correlated in mothers and daughters. Height, weight, and body composition were significantly correlated within mother-daughter pairs and could be a potential mechanism by which BMD is inherited. Among pre-and postmenopausal daughters, heritability estimates ranged from 50-63% and 34-48%, respectively. Heritability for calcaneal BUA (53%) was evident among postmenopausal daughters only. In conclusion, familial association in BMD was strongest among premenopausal daughters. Estimates of heritability suggest that maternal BMD and BUA are important independent predictors of BMD and BUA among daughters, reinforcing the importance of prevention and early intervention among women with a positive family history of osteoporosis. (J Bone Miner Res 1999;14:102-110)

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Danielson

Cauley

Baker

et al. 1999

Journal of Bone and Mineral Research

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show abstract

“…However, there is a strong genetic component to BD and an individual's genetic makeup is thought to contribute 60 -70% of the normal variability in BD, in combination with these other factors [4]. Knowledge of the influence of genetics on BD in humans has been obtained from twin studies [5,6], multigenerational family studies [7,8], and sib pair analyses [9].…”

Section: Introductionmentioning

confidence: 99%

Bone density in sheep: genetic variation and quantitative trait loci localisation

Campbell

Bain

McRae

et al. 2003

Bone

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Bone density (BD) is an important factor in osteoporotic fracture risk in humans. However, BD is a complex trait confounded by environmental influences and polygenic inheritance. Sheep provide a potentially useful model for studying differences in BD, as they provide a means of circumventing complex environmental factors and are a similar weight to humans. The aims of this study were to establish whether there is genetic variation in BD in sheep and then to localise quantitative trait loci (QTLs) associated with this variation. We also aimed to evaluate the relationship between fat and muscle body components and BD in sheep. Results showed that there was significant (P Ͻ 0.01) genetic variation among Coopworth sheep sires for BD. This genetic difference was correlated (P Ͻ 0.01) with body weight and muscle mass. A number of QTLs exceeding the suggestive threshold were identified (nine in total). Of these, two (chromosomes 1, P Ͻ 0.05; chromosome 24, P Ͻ 0.01) were significant using genome-wide permutation significance thresholds (2000 iterations). The position of the QTL on chromosome 24 coincided with a number of other body composition QTLs, indicating possible pleiotropic effects or the presence of multiple genes affecting body composition at that site. This study shows that sheep are potentially a useful model for studying the genetics of BD.

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“…Inbred mice offer unlimited numbers of genetically identical "twins" [17][18][19] whose environments can be strictly controlled. Comparisons among mouse strains have been used to identify genetic loci that contribute to levels of bone density in healthy mice.…”

Section: Introductionmentioning

confidence: 99%

Mouse Strain Dependent and Independent Effects of Type 1 Diabetic Bone Pathology

Zhang¹

2012

J Diabetes Metab

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Type 1 diabetes (T1D) contributes to bone loss in humans as well as in both spontaneous and pharmacologicinduced T1D mouse models. The severity of complications of T1D, such as nephropathy, differs in different mouse strains. However, the contribution of genetics in modifying the extent of T1D-induced bone loss has not been fully addressed. Here, we compare the T1D-induced bone pathology between three commonly used inbred mouse strains: Balb/c, C57BL/6 and 129/Sv mice. All T1D mouse strains displayed a characteristic bone phenotype characterized by significant bone loss, decreased levels of osteoblast markers and increased marrow adiposity. However, straindependent differences were also observed. Most notably, 129/Sv T1D mice displayed the greatest magnitude of bone loss despite having the least disease severity (as indicated by blood glucose levels) of the three strains studied. These findings suggest the contribution of strain dependent/genetically associated factors to the degree of bone loss observed in T1D mice.

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Familial comparison of bone mineral density at the proximal femur and lumbar spine

Cited by 57 publications

References 26 publications

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Bone density in sheep: genetic variation and quantitative trait loci localisation

Mouse Strain Dependent and Independent Effects of Type 1 Diabetic Bone Pathology

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