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Cited by 526 publications
(321 citation statements)
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“…Table III shows that formulations A and C allow a notable permeation of the drug after 8 h. Formulations B and D on the contrary display low permeated amount and low flux, the value related to the ointment D being the lowest one. Improved flux and permeation can result from the microemulsion components (surfactants and co-surfactants) (13,14); moreover also Transcutol is present in both types of microemulsions and it is well known that it significantly increases the percutaneous pene- tration of various active substances, particularly if used in combination with suitable cosolvents (15,16). This association is present in formulation C, where propylene glycol acts with a possible synergistic enhancer effect and this accounts first for the satisfactory solvent power and second for the skin penetration enhancing properties of the hydrophobic microemulsion (1) (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Table III shows that formulations A and C allow a notable permeation of the drug after 8 h. Formulations B and D on the contrary display low permeated amount and low flux, the value related to the ointment D being the lowest one. Improved flux and permeation can result from the microemulsion components (surfactants and co-surfactants) (13,14); moreover also Transcutol is present in both types of microemulsions and it is well known that it significantly increases the percutaneous pene- tration of various active substances, particularly if used in combination with suitable cosolvents (15,16). This association is present in formulation C, where propylene glycol acts with a possible synergistic enhancer effect and this accounts first for the satisfactory solvent power and second for the skin penetration enhancing properties of the hydrophobic microemulsion (1) (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This process enhances the ultimate effector mechanisms of FGF-2, including cell proliferation and metastasis in cancer cells (25,26). Liposomes are known to facilitate the penetration of drugs through cellular membranes and tissue (27). Liposomal embedding of syndecan-4 could facilitate the passage of FGF-2 through the cytoplasmic, endosomal, and nuclear membranes of the cell.…”
Section: Discussionmentioning
confidence: 99%
“…A literatura 18,[29][30][31][32] considera que um sistema disperso para ser considerado ME é necessário que o tamanho de suas gotículas da fase interna esteja entre 10 e 150 nm. Por isso, podemos estimar que o sistema estudado seja uma MEG, bem como podemos utilizá-la para realização dos estudos posteriores.…”
Section: Caracterização Físico-química Da Megunclassified
“…1,30 No entanto, neste estudo, foi encontrado resultado contraditório, pois a MEG apresentou uma menor quantidade liberada e permeada, respectivamente, que o emulgel genérico (Figuras 3 e 4), fato que pode ser atribuído a uma diminuição da mobilidade do DDA incorporado, o que se traduziu numa difusão mais lenta e J diminuído.…”
Section: Caracterização Físico-química Da Megunclassified