1997
DOI: 10.1016/s0092-8674(00)81873-5
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Abstract: condense, and the organelles and plasma membrane retain their integrity in a process Kerr and his colleagues and Martin C. Raff Developmental Neurobiology Programme named apoptosis. The dead cells or their fragments are rapidly phagocytosed by neighboring cells or macro-MRC Laboratory for Molecular Cell Biology University College London phages before there is any leakage of the contents of the cells, and thus they do not induce an inflammatory London, WC1E 6BT United Kingdom response. Apoptotic cells in develo… Show more

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Cited by 2,497 publications
(1,609 citation statements)
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“…Apoptosis is a fundamental important biological process that is required to maintain the integrity and homeostasis of multicellular organism [1]. It seems that apoptosis is a predominant type of active cell death in the liver.…”
Section: Introductionmentioning
confidence: 99%
“…Apoptosis is a fundamental important biological process that is required to maintain the integrity and homeostasis of multicellular organism [1]. It seems that apoptosis is a predominant type of active cell death in the liver.…”
Section: Introductionmentioning
confidence: 99%
“…Although our knowledge of the mechanisms involved in the regulation of this process has grown considerably in the last few years, our understanding of the function as well as the nature of the genes involved in this process remains incomplete (Jacobson et al, 1997;Nagata, 1997). Genetic studies in C. elegans have led to the identi®cation of three genes ced-3, ced-4 and ced-9 involved in the central regulation of the apoptotic process (Ellis and Horvitz, 1986;Ellis et al, 1991;Hengartner et al, 1992).…”
Section: Introductionmentioning
confidence: 99%
“…Macrophages acting as professional phagocytes are capable of engulfing apoptotic cells undergoing type I PCD without inducing inflammatory response. 14,15 Typical examples of this clearance are found during embryonic development when a large number of apoptotic cells are removed 16 and during clearance of apoptotic granulocytes in inflammation. 17 Many cells of different origin, including epithelial cells, can act as non-professional phagocytes and engulf apoptotic cells.…”
mentioning
confidence: 99%