Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters

Sudesh, Kumar; Abe, Hideki; Doi, Yoshiharu

doi:10.1016/s0079-6700(00)00035-6

Cited by 1,905 publications

(1,354 citation statements)

References 291 publications

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“…PHA has many advantages, such as biodegradability and biocompatibility, compared to petroleum-based plastics while exhibiting thermal and mechanical properties similar to existing plastics (Sudesh et al 2000). As a result, PHA can be used as a raw material to manufacture many different plastic products including biomedical devices, drink bottles, food packaging, etc.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha

Jeon

Brigham

Kim

et al. 2014

Appl Microbiol Biotechnol

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Polyhydroxyalkanoates (PHAs), a promising family of bio-based polymers, are considered to be alternatives to traditional petroleum-based plastics. Copolymers like poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) have been shown to exhibit favorable physical and mechanical properties, due to decreased crystallinity resulting from the presence of medium-chain-length 3-hydroxyhexanoate (3HHx) monomers. In this study, we produced P(HB-coHHx) using engineered Ralstonia eutropha strains containing deletions of the acetoacetyl-CoA reductase (phaB) genes and replacing the native PHA synthase with phaC2 from Rhodococcus aetherivorans I24 and by using butyrate, a short-chain organic acid, as the carbon source. Although the wild-type R. eutropha did not produce P(HB-co-HHx) when grown on mixed acids or on butyrate as the sole carbon source, we are able to produce polymer containing up to 40 wt% 3HHx monomer with the aforementioned engineered R. eutropha strains using various concentrations of just butyrate as the sole carbon source. This is the first report for the production of P(HB-co-HHx) copolymer in R. eutropha using butyrate.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha

Jeon

Brigham

Kim

et al. 2014

Appl Microbiol Biotechnol

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“…One of the methods by which they are obtained is polymerisation reaction with opening of the β-lactone ring described in [14]. The scheme of PHA structure [3] A representative of PHA is PHB, a natural aliphatic polymer produced as a reserve material by such bacteria as: Psudomonas, Bacillus, Azotobacter [15,16]. Biologically, PHB is synthesised by bacterial fermentation of glucose, most commonly as a result of sugarcane sucrose processing, and less frequently, both for technical and economic reasons, from maize starch glucose.…”

Section: Materials and Research Methodsmentioning

confidence: 99%

PLA/PHA-Biodegradable Blends for Pneumothermic Fabrication of Nonwovens

Szuman

Krucińska

Boguń

et al. 2016

Autex Research Journal

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This study presents the results of research concerning fabrication of nonwovens from biodegradable polymer blends using the melt-blown method. The experiments performed within the framework of the research confirmed the possibility of obtaining polymer composites based on polylactide (PLA) with poly(hydroxyalkanoates) (PHA) and another aliphatic-aromatic copolyester. The obtained products were subjected to the analyses of chemical structure using the Fourier Transform Infrared Spectroscopy(FTIR) Attenuated Total Reflectance(ATR) method. The physical and mechanical properties of the fabricated nonwoven layers were also tested, which confirmed a wide spectrum of their applicability, depending on the polymer composition used in production.

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“…Polyhydroxyalkanoates (PHAs) are a class of aliphatic polyesters that accumulate in various bacteria under nutrient-limited conditions, acting as carbon and energy storage materials (Chen 2009;Sudesh et al 2000). To date, PHAs have attracted much attention, as they possess properties similar to common thermoplastics.…”

Section: Introductionmentioning

confidence: 99%

Advanced functionalization of polyhydroxyalkanoate via the UV-initiated thiol-ene click reaction

Tajima

Iwamoto

Satoh

et al. 2016

Appl Microbiol Biotechnol

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Polyhydroxyalkanoates (PHAs) incorporating vinyl-bearing 3-hydroxyalkanoates were prepared in 8.5-12.9 g·L -1 yield. The molar ratios (0-16 mol%) of the vinyl-bearing 3-hydroxyalkanoate derivatives were controlled by the continuous feeding of undecylenate at various concentrations. Subsequently, the PHAs were functionalized by UV-initiated thiolene click reaction and chemical modification. 1 H NMR spectra suggested that 3-mercaptopropionic acid and 2-aminoethanthiol were successfully introduced into the vinylbearing PHA. Subsequently, chemical modification using fluorescein or a fibronectin active fragment (GRGDS) was attempted. The former yielded a PHA derivative capable of emitting fluorescence under UV irradiation, which was useful for determining the miscibility of PHA in a composite film comprising poly-ʟ-lactic acid (PLLA) and PHA. In the latter case, PHA bearing GRGDS peptides exhibited cell adhesiveness, suggesting that its biocompatibility was improved upon peptide introduction. Taken together, the UV-initiated thiol-ene click reaction was demonstrated to be useful in PHA modification.

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Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters

Cited by 1,905 publications

References 291 publications

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha

PLA/PHA-Biodegradable Blends for Pneumothermic Fabrication of Nonwovens

Advanced functionalization of polyhydroxyalkanoate via the UV-initiated thiol-ene click reaction

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