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Cited by 390 publications
(32 citation statements)
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“…Cleavage of PARP is probably not directly important in the cell-death mechanism, as PARPdeficient mice develop normally and do not show significant perturbations of apoptosis [43]. The list of death substrates and potential targets for ICE-like proteases is growing and includes the nuclear lamins [44,45], the 70 kDa component of U1 small nuclear ribonucleoprotein (U1-70 kDa snRNP) [46,47], D4 guanine nucleotide dissociation inhibitor (D4-GDI) [48], sterol regulatory element binding proteins (SREBPs) [49] and protein kinase C ␦ (PKC␦) [50]. It is not yet clear whether the cleavage of any of these substrates is important in the execution phase of apoptosis.…”
Section: Ced-3 Subfamily Ice Subfamily Nedd-2 Subfamilymentioning
confidence: 99%
“…Cleavage of PARP is probably not directly important in the cell-death mechanism, as PARPdeficient mice develop normally and do not show significant perturbations of apoptosis [43]. The list of death substrates and potential targets for ICE-like proteases is growing and includes the nuclear lamins [44,45], the 70 kDa component of U1 small nuclear ribonucleoprotein (U1-70 kDa snRNP) [46,47], D4 guanine nucleotide dissociation inhibitor (D4-GDI) [48], sterol regulatory element binding proteins (SREBPs) [49] and protein kinase C ␦ (PKC␦) [50]. It is not yet clear whether the cleavage of any of these substrates is important in the execution phase of apoptosis.…”
Section: Ced-3 Subfamily Ice Subfamily Nedd-2 Subfamilymentioning
confidence: 99%
“…Finally, Moss and coworkers demonstrated that the deamidation of asparagine residues in tetanus toxin C fragment inhibits the processing by asparagine endopeptidase and results in decreased antigen processing (181). The role of PTMs in antigen processing was examined years ago in studies of model proteins in immunity (168,(182)(183)(184). An isoaspartylated form of cytochrome c protein is cleaved differently by cathepsin D compared to the (normal) aspartyl form of the same protein (2).…”
Section: Ptms In Antigen Processing and Presentationmentioning
confidence: 99%
“…They suffer significant changes during apoptosis (80); this changes involve the rRNA degradation by the Fas pathway, which occurs at the 3'-end region of 28S rRNA, therefore the caspase-3 expose part of the large subunit; additionally, different ribonucleases caspase dependent (CARs) are activated and produce extrusion of the nuclear RNP structures to the cell surface; also during apoptosis mRNAs are cleaved previously to eIF4GI and other initiation factors, this cleavage may result in anti-nucleolar antibody production in diseases like scleroderma (81)(82)(83)(84)(85). Patients suffering of the autoimmune mixed connective tissue disease produce huge amounts of anti-U1-70RNP autoantibody, and this ribonucleoprotein is one of the most affected by apoptosis, therefore the caspase 3 cleaves U1 70 RNP at position 338 DGPD 341 , and the fragmentation increases its antigenicity (86)(87)(88); interestingly the anti-RNP autoantibodies recognize preferentially the apoptotic epitope of U1-70K (89).…”
Section: Apoptosis Affects the Nucleolus And Nucleoplasmic Rnp Containing Structuresmentioning
confidence: 99%