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Cited by 125 publications
(77 citation statements)
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References 30 publications
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“…21,22) First AHs have been suggested to have analgesic effects on both somatic and visceral pain. 17) In the present study, 1st AHs exhibited analgesic effects in the writhing test in both C3H/HeN and H1R-KO mice.…”
Section: Discussionsupporting
confidence: 53%
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“…21,22) First AHs have been suggested to have analgesic effects on both somatic and visceral pain. 17) In the present study, 1st AHs exhibited analgesic effects in the writhing test in both C3H/HeN and H1R-KO mice.…”
Section: Discussionsupporting
confidence: 53%
“…17) However, in the present study, the writhing responses of male and female H1R-KO mice were not different from those shown by male and female C57BL/6N mice (nor from those of male or female BALB or male C3H/HeN mice) (Fig. 1A).…”
Section: H1r-ko and C3h/hen Mice Are Useful For The Writhing Test Thecontrasting
confidence: 62%
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“…injection of histamine induces CGRP release into the CSF (Bileviciute et al, 1994) and (iii) histamine administered to the nasal mucosa causes CGRP release from the peripheral terminals of trigeminal ganglion in the guinea pig (Tani et al, 1990). Further support for this link between histamine and CGRP is attained from the observed co-localization of the histamine H3 receptor with CGRP on Aδ fibres, with both mediators contributing to a high-threshold mechanical nociceptive effect (Cannon et al, 2007).More recently, it has been demonstrated that both the H1 receptor antagonist pyrilamine and the H2 receptor antagonist ranitidine produce dose-dependent antinociceptive responses in the formalin test, and that hyperalgesia induced by intrathecal administration of histamine is attenuated by the GCRP antagonist CGRP 8-37 (Mobarakeh et al, 2011).Studies with histamine H1 receptor knockout mice have demonstrated that both the receptor and its natural ligand are needed to facilitate pain transmission at both the peripheral and central levels (Mobarakeh et al, 2000;. In addition, using histidine decarboxylase (HDC) gene knockout mice, it was shown that NK 1 receptors in the spinal cord mediate the histamine-induced hyperalgesic responses (Yoshida et al, 2005).…”
mentioning
confidence: 99%
“…For example, ReN-1869 is a novel selective H 1 receptor antagonist that has been developed for analgesic purpose [1]. It has been reported that histamine H 1 receptor knockout mice showed decreased sensitivity to nociceptive stimuli [2]. In the periphery, histamine release from the injured tissue, mast cells, and basophils led to activation of paintransmitting nerve fibers and also increases the release of pain-related neuropeptides [3].…”
Section: Introductionmentioning
confidence: 99%