2000
DOI: 10.1016/s0008-6363(99)00388-0
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Abstract: In view of such results, we believe that the decrease of respiratory chain complex III activity found in some cases of IDC is a secondary phenomenon, and not due to a primary mitochondrial disease.

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Cited by 172 publications
(111 citation statements)
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“…Most patients have multisystemic dysfunction with isolated cardiomyopathy rarely described [70,99]. What has been difficult to prove is in which patients, was mitochondrial dysfunction primary or secondary to a failing heart [100,101]. Several studies have demonstrated mitochondrial dysfunction in both cardiac aging and cardiac disease [102,103].…”
Section: Cardiac Muscle Analysismentioning
confidence: 99%
“…Most patients have multisystemic dysfunction with isolated cardiomyopathy rarely described [70,99]. What has been difficult to prove is in which patients, was mitochondrial dysfunction primary or secondary to a failing heart [100,101]. Several studies have demonstrated mitochondrial dysfunction in both cardiac aging and cardiac disease [102,103].…”
Section: Cardiac Muscle Analysismentioning
confidence: 99%
“…BN-PAGE and SDS-PAGE were carried out by established methods with minor modifications [9,26,38]. Briefly, a 5 to 12% acrylamide gradient was used for the first dimension BN-PAGE, imidazole instead of Bis-Tris was used as a buffer, and Criterion 10-20% 2D-well gels (BioRad, CA) were used for the second dimension SDS-PAGE.…”
Section: Polyacrylamide Gel Electrophoresismentioning
confidence: 99%
“…Citrate synthase activity was measured as described [22,30]. Rotenone-sensitive Complex I (CI) activity, malonate-sensitive Complex II (CII) activity, antimycin A-sensitive Complex III (CIII) activity, KCN-sensitive Complex IV (CIV) activity, and oligomycin-sensitive Complex V (CV) activities were assayed as described [22,27,31].…”
Section: Enzyme Activitiesmentioning
confidence: 99%