Synthesis of some cluster glycosides suitable for attachment to proteins or solid matrices

Yuan, Chuan Lee

doi:10.1016/s0008-6215(00)84141-5

Cited by 119 publications

(2 citation statements)

References 11 publications

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“…[111] One of the very first glycodendrimer synthesis was reported by Yuan. [112] However, STARFISH was the first therapeutically significant development of an oligovalent dendron-like complex having analogs of Gb3 trisaccharide (Pk) covalently linked to the pentavalent glucose moiety (Figure 5b). It is well known that Gb3 carbohydrate is a ligand for the E. coli-based Shiga-like contaminants.…”

Section: Polyvalent Glycoengineered Molecules and Inhibitorsmentioning

confidence: 99%

A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

Gadekar

Bhowmick

Pandit

2020

Adv Funct Materials

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In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery field became surpassed by protein and DNA-focused treatments. However, the emergence of new analytical tools and methods to synthesize structurally specific glycans has encouraged and motivated the scientific community toward the development of glycan-based therapeutics. This review discusses the reemergence of glycan-based agents in the last decade and the technical strategies that played a key role in bringing the glycanbased treatments into the limelight of modern medicine. The review also includes the application of native glycans as the therapeutic agents along with the chemically engineered cell surface glycans and proteins to meet the preclinical and clinical scenario. Glycan-based therapeutic materials hold a huge potential that can be harnessed to meet the clinical needs in medicine.

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Section: Polyvalent Glycoengineered Molecules and Inhibitorsmentioning

confidence: 99%

A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

Gadekar

Bhowmick

Pandit

2020

Adv Funct Materials

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“…Dendrimers are single molecular weight, globular structures which contain a central core, branching layers, and numerous functionalized end groups (Newkome and Shreiner, 2008, 2010). Though glycodendrimers have been synthesized for decades (Yuan, 1978), one of the first therapeutically relevant successes was the design of STARFISH; an oligovalent dendron-like compound bearing Gb 3 trisaccharide analogs (P k ) attached to a glucose pentavalent core (Figure 3A). The Gb 3 glycan is a known ligand for the multimeric Shiga-like toxins I and II, found in pathogenic E. coli .…”

Section: Engineered Glycans and Glycan Mimics As Therapeutic Agentsmentioning

confidence: 99%

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

Hudak

Bertozzi

2014

Chemistry & Biology

203

173

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The beginning of the 20th century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest in the therapeutic applications of glycans. This review focuses on advances within the past decade that are bringing glycan-based treatments back to the forefront of medicine and the technologies that are driving these efforts. These include the use of glycans themselves as therapeutic molecules as well as engineering protein and cell surface glycans to suit clinical applications. Glycan therapeutics offer a rich and promising frontier for developments in the academic, biopharmaceutical, and medical fields.

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Ein allgemeiner Syntheseweg für die Herstellung von Glycopeptid-„Dendrons”

Sadalapure

2000

Angewandte Chemie

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Synthesis of some cluster glycosides suitable for attachment to proteins or solid matrices

Cited by 119 publications

References 11 publications

A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

Ein allgemeiner Syntheseweg für die Herstellung von Glycopeptid-„Dendrons”

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