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Cited by 48 publications
(10 citation statements)
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References 39 publications
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“…It is tempting to speculate that the ROS-independent downregulation of Bcl-2 and Mcl-1, observed after 4-oxo-4-HPR treatment, could play a role in the apoptosis induced by the antimicrotubule activity of the retinoid, although at present no evidence supports this hypothesis. According to our observations, it has been reported that treatment with other microtubule-interfering agents can lead to a decrease in Bcl-2 and Mcl-1 intracellular amounts contributing to apoptosis [23][25].…”
Section: Discussionsupporting
confidence: 59%
“…It is tempting to speculate that the ROS-independent downregulation of Bcl-2 and Mcl-1, observed after 4-oxo-4-HPR treatment, could play a role in the apoptosis induced by the antimicrotubule activity of the retinoid, although at present no evidence supports this hypothesis. According to our observations, it has been reported that treatment with other microtubule-interfering agents can lead to a decrease in Bcl-2 and Mcl-1 intracellular amounts contributing to apoptosis [23][25].…”
Section: Discussionsupporting
confidence: 59%
“…The increased stathmin level was correlated with the increased polymerized tubulin and tyrosine-phosphorylated p34 Cdc2 in the two resistant cells. Characteristically, the Ptx-resistant cell lines also expressed more of the antiapoptotic protein Bcl2 ( Figure 5) and less of the proapoptotic protein Bax (Poruchynsky et al, 2001), a phenotype that is associated with chemoresistance in aggressive tumors (Reed, 1995). The sum of these results implicates an important role for stathmin in the Ptx resistance of these cells.…”
Section: Discussionmentioning
confidence: 91%
“…The two Ptx-resistant lines have point mutations in the major b-tubulin gene, M40 (1A9/Ptx-10: codon 270, Phe-Val; 1A9/Ptx-22: codon 364, Ala-Thr) as well as point mutations in one or both alleles of the TP53 gene (1A9/Ptx-10: codon 236, Tyr-Cys in one allele leading to a dominant-negative p53 phenotype; 1A9/Ptx-22: codon 239, Asn-Asp in both alleles) (Giannakakou et al, 2000). Previous work has also shown these resistant lines to express lower levels of Bax (Poruchynsky et al, 2001). In this study, the expression of stathmin in these cells was found to be independent of p53/p21 WAF1/Cip1 regulation.…”
Section: Introductionmentioning
confidence: 99%
“…An association between MAP4 and paclitaxel resistance has been observed in different cancer types including ovarian cancer (Poruchynsky et al 2001; Orr et al 2003; Aoki et al 2009). In the chemotherapy-naïve cases of the current study, the correlation between high MAP4 expression and chemo-sensitisation was statistically significant in patients treated by taxane-containing chemotherapy ( χ 2  = 4.596, df  = 1, P  = 0.032).…”
Section: Discussionmentioning
confidence: 99%