Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis)

Wunderink, Yvette S.; Vrieze, Erik de; Metz, Juriaan R.; Halm, Silke; Martı́nez-Rodrı́guez, Gonzalo; Flik, G.; Klaren, Peter H.M.; Mancera, Juan Miguel

doi:10.1016/j.ygcen.2011.11.026

Cited by 23 publications

(9 citation statements)

References 37 publications

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“…Regarding the anorexigenic peptides, CART and POMC mRNA levels are elevated under acute stress conditions in zebrafish ( 80 ), but no changes or decreased levels were found in rainbow trout after chronic crowding stress ( 38 , 52 ). Other studies also found decreased POMC levels in sole under high stocking density ( 82 , 83 ). These results suggest a complex response depending on the species and the type of stress.…”

Section: Effect Of Stress On the Hypothalamic Integration Of The Appementioning

confidence: 66%

Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish

et al. 2018

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The homeostatic regulation of food intake relies on a complex network involving peripheral and central signals that are integrated in the hypothalamus which in turn responds with the release of orexigenic or anorexigenic neuropeptides that eventually promote or inhibit appetite. Under stress conditions, the mechanisms that control food intake in fish are deregulated and the appetite signals in the brain do not operate as in control conditions resulting in changes in the expression of the appetite-related neuropeptides and usually a decreased food intake. The effect of stress on the mechanisms that regulate food intake in fish seems to be mediated in part by the corticotropin-releasing factor (CRF), an anorexigenic neuropeptide involved in the activation of the HPI axis during the physiological stress response. Furthermore, the melanocortin system is also involved in the connection between the HPI axis and the central control of appetite. The dopaminergic and serotonergic systems are activated during the stress response and they have also been related to the control of food intake. In addition, the central and peripheral mechanisms that mediate nutrient sensing capacity and hence implicated in the metabolic control of appetite are inhibited in fish under stress conditions. Finally, stress also affects peripheral endocrine signals such as leptin. In the present minireview, we summarize the knowledge achieved in recent years regarding the interaction of stress with the different mechanisms that regulate food intake in fish.

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Section: Effect Of Stress On the Hypothalamic Integration Of The Appementioning

confidence: 66%

Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish

et al. 2018

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“…At the pituitary level, two proopiomelanocortin (Pomcs) have been described in several teleost species to participate in the endocrine stress response, including S. aurata (Cardoso et al, 2011 ; Wunderink et al, 2012 ; Saccol et al, 2018 ): (i) Pomca, responsible for α-Msh synthesis, and (ii) Pomcb, responsible for Acth production. In our study, both precursos showed different pattern of changes (Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Air Exposure on Vasotocinergic and Isotocinergic Systems in Gilthead Sea Bream (Sparus aurata): New Insights on Fish Stress Response

et al. 2018

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The hypothalamus-pituitary-interrenal (HPI) and hypothalamus-sympathetic-chromaffin cell (HSC) axes are involved in the regulation of the stress response in teleost. In this regard, the activation of a complex network of endocrine players is needed, including corticotrophin-releasing hormone (Crh), Crh binding protein (Crhbp), proopiomelanocortin (Pomc), thyrotropin-releasing hormone (Trh), arginine vasotocin (Avt), and isotocin (It) to finally produce pleiotropic functions. We aimed to investigate, using the gilthead sea bream (Sparus aurata) as a biological model, the transcriptomic response of different endocrine factors (crh, crhbp, pomcs, trh), neuropeptides (avt and it), and their specific receptors (avtrv1a, avtrv2, and itr) in four important target tissues (hypothalamus, pituitary, kidney and liver), after an acute stress situation. We also investigated several stress hormones (catecholamines and cortisol). The stress condition was induced by air exposure for 3 min, and hormonal, metabolic and transcriptomic parameters were analyzed in a time course response (15 and 30 min, and 1, 2, 4, and 8 h post-stress) in a total of 64 fish (n = 8 fish per experimental group; p = 0.05; statistical power = 95%). Our results showed that plasma noradrenaline, adrenaline and cortisol values increased few minutes after stress exposure. At hypothalamic and hypophyseal levels, acute stress affected mRNA expression of all measured precursors and hormonal factors, as well as their receptors (avtrs and itr), showing the activation, at central level, of HPI, HSC, and Avt/It axes in the acute stress response. In addition, stress response also affected mRNA levels of avtrs and itr in the head kidney, as well as the steroidogenic acute regulatory protein (star) and tyrosine hydroxylase (th) expression, suggesting their participation in the HPI and HSC axes activation. Moreover, the pattern of changes in hepatic avtrs and itr gene expression also highlights an important role of vasotocinergic and isotocinergic pathways in liver metabolic organization after acute stress events. Our results demonstrate, both at transcriptional and circulating levels of several hormones, the existence of a complex activation of different endocrine pathways in S. aurata related to the stress pathways, where vasotocinergic and isotocinergic systems can also be considered key players of the acute stress response orchestration.

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“…Melanocortins, the product of POMC gene, involve energy expenditure and sexual activity when bound to melanocortin receptors in brain (Ducrest, Keller, & Roulin, ). In some teleost fish, pomca (a paralog gene) is related to the neuroendocrine stress response and its expression is downregulated under chronic stress exposure (Wunderink et al., ). Taken together, the significant representation of hormone activity by some DE genes suggests that warm prereproduction conditions probably suppress growth and early reproductive investment in male sticklebacks as supported by our results of life‐history plasticity (Figure ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional mechanisms underlying life‐history responses to climate change in the three‐spined stickleback

Kim

Costa

Esteve‐Codina

et al. 2017

Evolutionary Applications

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Phenotypic plasticity, the ability of an organism to express different phenotypes depending on the environment, provides an important mechanism by which an animal population can persist under rapid climate change. We experimentally tested both life‐history and transcriptional responses of an ecological model species, the three‐spined stickleback, to warm acclimation at the southern edge of its European range. We explored cross‐environment genetic correlations of key life‐history traits in male sticklebacks exposed to long‐term temperature changes to examine whether the plasticity pattern was variable among genotypes by using a character‐state approach. We also studied gene expression plasticity by analysing both whole‐transcriptome and candidate gene expression in brain and liver. Male sticklebacks that developed under warmer conditions during winter were smaller in size and invested less in nuptial coloration at the beginning of the breeding season, showing similar responses across different genotypes. The lack of genetic variation in life‐history responses may limit any future evolution of the thermal reaction norm in the study population. After long‐term exposure to increased winter temperatures, genes responsible for several metabolic and oxidation–reduction processes were upregulated, and some hormone genes involved in growth and reproduction were downregulated in the brain. In the liver, there was no significantly represented gene ontology by the differentially expressed genes. Since a higher temperature leads to a higher resting metabolic rate, living in warmer environments may incur higher energetic costs for ectotherms to maintain cellular homoeostasis, resulting in negative consequences for life‐history traits. The expression of genes related to metabolism, cellular homoeostasis and regulatory signalling may underlie temperature‐induced changes in life history.

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Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis)

Cited by 23 publications

References 37 publications

Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish

Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish

Impact of Air Exposure on Vasotocinergic and Isotocinergic Systems in Gilthead Sea Bream (Sparus aurata): New Insights on Fish Stress Response

Transcriptional mechanisms underlying life‐history responses to climate change in the three‐spined stickleback

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