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Cited by 73 publications
(50 citation statements)
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References 26 publications
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“…However, previous analysis of THs during embryo development in fathead minnow also showed a significant rise in both T4 and T3 during the prehatch period, indicating embryonic production of both thyroid hormones and significantly increased synthesis of THs in an early developmental stage after hatching in fish. 24,25 In the present study, TH levels were increased in the larvae and the expressions of genes related to thyroid development and growth (e.g., hhex, nkx2.1) and TH synthesis (e.g., TG) were all significantly up-regulated as well, indicating that the increased THs in the larvae could also be …”
Section: ' Discussionsupporting
confidence: 55%
“…However, previous analysis of THs during embryo development in fathead minnow also showed a significant rise in both T4 and T3 during the prehatch period, indicating embryonic production of both thyroid hormones and significantly increased synthesis of THs in an early developmental stage after hatching in fish. 24,25 In the present study, TH levels were increased in the larvae and the expressions of genes related to thyroid development and growth (e.g., hhex, nkx2.1) and TH synthesis (e.g., TG) were all significantly up-regulated as well, indicating that the increased THs in the larvae could also be …”
Section: ' Discussionsupporting
confidence: 55%
“…However, fish larval stages are believed to be more sensitive to toxic chemicals than adults. Hence it is important to investigate effects of potential thyroid disruptors in early life stages, and understanding the patterns of TH throughout development may reveal sensitive windows during which thyroid disruption could have particular importance (Crane et al, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…The exposure concentrations were based on a previous range finding study which revealed that after exposure to the lowest concentration of BDE-209 (0.08 mg/L), the malformation rates showed an increasing but not statistically significant trend. The embryos were exposed until 14 days post-fertilization (dpf) during a stage when TH synthesis is at the highest levels in fathead minnow larvae (Crane et al, 2004). During the experimental period, the exposure solution was renewed daily, and zebrafish larvae were fed with cultured live paramecia and Artemia twice daily.…”
Section: Zebrafish Maintenance and Embryo Exposurementioning
confidence: 99%
“…The selected exposure concentrations were previously ascertained by performing a range-finding study; this study revealed that after exposure to the lowest concentration of DE-71 (1 g/L), the malformation rates showed a trend toward an increase but the tendency was not statistically significant. The exposure time used in our experiment was chosen on the basis of a previous report that indicated that TH synthesis in the fathead minnow larvae was highest at 14 days (Crane et al, 2004). The larvae were randomly sampled at 14 dpf, immediately frozen in liquid nitrogen, and stored at −80 • C for performing analysis of gene transcription and TH assays.…”
Section: Zebrafish Maintenance and Exposure Of Embryos To De-71mentioning
confidence: 99%