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Cited by 129 publications
(40 citation statements)
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“…The SSRIs were developed for humans but may equally influence aquatic organisms at different trophic levels and ultimately disturb natural food webs and thus aquatic communities. It has been demonstrated that SSRIs bioconcentrate in different fish tissues, particularly the brain, and in other aquatic organisms in the aquatic food chain (Brooks et al 2005;Nakamura et al 2008;Schultz et al 2010;Grabicova et al, 2014Grabicova et al, , 2015Boström et al 2017). The SERTs are comparable across different vertebrate taxa, and the 5-HT system is remarkably conserved in animal evolution (Wang et al 2006;Lillesaar 2011).…”
Section: Introductionmentioning
confidence: 99%
“…The SSRIs were developed for humans but may equally influence aquatic organisms at different trophic levels and ultimately disturb natural food webs and thus aquatic communities. It has been demonstrated that SSRIs bioconcentrate in different fish tissues, particularly the brain, and in other aquatic organisms in the aquatic food chain (Brooks et al 2005;Nakamura et al 2008;Schultz et al 2010;Grabicova et al, 2014Grabicova et al, , 2015Boström et al 2017). The SERTs are comparable across different vertebrate taxa, and the 5-HT system is remarkably conserved in animal evolution (Wang et al 2006;Lillesaar 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Many analytical methods rely on measurement of total radioactivity of a labelled compound using liquid scintillation counting (LSC) (Arnot and Gobas, 2006) as an alternative to confirmatory analytical tools based on liquid chromatography (LC) or gas chromatography (GC) coupled to mass spectrometry (MS). However for small freshwater invertebrates, only a few published LC or GC-MS-based methods exist for parent compound determination (Grabicova et al., 2015, Inostroza et al., 2016, Miller et al., 2015, Sordet et al., 2016). A reason for the small number of published methods is that sensitivity at environmentally relevant concentrations is often challenging due to their small size.…”
Section: Introductionmentioning
confidence: 99%
“…Agricultural soil exposure is derived from sludge concentrations of pharmaceuticals in WWTPs, which is the result of sorption characterized by the sludge/water partition coefficient (Kd) (Berthod et al 2017 The absence of ecotoxicity data or validated ecotoxicity models available, is another factor which may have contributed to the scope of reviewed prioritizations encapsulating only the water column. There is evidence that drugs were detected in invertebrate organisms in benthos and soil (Grabicova et al 2015;Heye et al 2016;Karlsson et al 2016;Kinney et al 2008); therefore, risks to these compartments needs to be considered. In addition, potential risks to predators and humans have, with a few exceptions (Murray-Smith et al 2012;Guo et al 2016), been overlooked, despite recent findings to suggest that these risks may be present (Wang et al 2016;Mottaleb et al 2016;Franklin et al 2016;Malchi et al 2014;Oaks et al 2004).…”
Section: Limitations and Opportunities With Current Methodologiesmentioning
confidence: 99%