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Cited by 26 publications
(11 citation statements)
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“…However, there is one particular substrate class that is conspicuously absent: α,β‐unsaturated amides. These compounds are less prone to nucleophilic attack due to the donation of the electrons on nitrogen into the conjugated π system, thus drastically reducing their electrophilicity towards nucleophiles . One approach to circumvent this is the introduction of activating/protecting groups to the amido functionality, increasing the extent of electron delocalization and thus rendering such amides more susceptible to nucleophilic attack.…”
Section: Advancement To Catalysis: Phosphapalladacycles As Efficient mentioning
confidence: 99%
“…However, there is one particular substrate class that is conspicuously absent: α,β‐unsaturated amides. These compounds are less prone to nucleophilic attack due to the donation of the electrons on nitrogen into the conjugated π system, thus drastically reducing their electrophilicity towards nucleophiles . One approach to circumvent this is the introduction of activating/protecting groups to the amido functionality, increasing the extent of electron delocalization and thus rendering such amides more susceptible to nucleophilic attack.…”
Section: Advancement To Catalysis: Phosphapalladacycles As Efficient mentioning
confidence: 99%
“…Among a variety of conjugated unsaturated systems are α,β‐ethylenic compounds such as methyl vinyl ketone, acrylonitrile, acrylate, acrylamide and vinyl sulfones were found to be particularly successful to be aza‐Michael addition acceptors. 1,2‐Addition of amines to unsaturated conjugated systems is also known similarly …”
Section: Introductionmentioning
confidence: 99%
“…1,2-Addition of amines to unsaturated conjugated systems is also known similarly. [12] On the other hand, several reports have published the biological properties of natural or synthesized chalcones, which include antiinflammatory, antitumour, antifungal. and antibacterial.…”
Section: Introductionmentioning
confidence: 99%
“…Upon close inspection of previous reports on the classes of substrates suitable for asymmetric hydrophosphination (AHP), it was surprising to note the stark absence of α,β‐unsaturated amides as favourable acceptors in the presence of phosphorus nucleophiles. This can be attributed to the tendency of nitrogen to donate electrons into the conjugated system, leading to a drastic reduction in electrophilicity at the β‐carbon 14. One solution involves the introduction of activating‐protecting groups to the amide functionality.…”
Section: Introductionmentioning
confidence: 99%
“…This can be attributed to the tendency of nitrogen to donate electrons into the conjugated system, leading to a drastic reduction in electrophilicity at the b-carbon. [14] One solution involves the introduction of activating-protecting groups to the amide functionality. However, in some instances, activation may not suffice, leading to the requirement for increased catalyst loading and longer reaction times to achieve the desired conjugate addition.…”
Section: Introductionmentioning
confidence: 99%