An ultrasensitive homogeneous aptasensor for carcinoembryonic antigen based on upconversion fluorescence resonance energy transfer

Wang, Yujie; Wei, Zikai; Luo, Xianda; Wan, Quan; Qiu, Rongliang; Wang, Shizhong

doi:10.1016/j.talanta.2018.11.011

Cited by 50 publications

(15 citation statements)

References 36 publications

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“…As shown in Figure 5 , Wang et al [ 89 ] designed an ultra-sensitive homogeneous aptamer biosensor for CEA detection based on the fluorescence resonance energy transfer (FRET) between the upconversion nanoparticles (UCNPs) and graphene oxide (GO). UCNPs modified with a CEA aptamer were immobilized on the GO surface by π–π stacking.…”

Section: Biosensormentioning

confidence: 99%

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A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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Breast cancer has the highest cancer incidence rate in women. Early screening of breast cancer can effectively improve the treatment effect of patients. However, the main diagnostic techniques available for the detection of breast cancer require the corresponding equipment, professional practitioners, and expert analysis, and the detection cost is high. Tumor markers are a kind of active substance that can indicate the existence and growth of the tumor. The detection of tumor markers can effectively assist the diagnosis and treatment of breast cancer. The conventional detection methods of tumor markers have some shortcomings, such as insufficient sensitivity, expensive equipment, and complicated operations. Compared with these methods, biosensors have the advantages of high sensitivity, simple operation, low equipment cost, and can quantitatively detect all kinds of tumor markers. This review summarizes the biosensors (2013–2021) for the detection of breast cancer biomarkers. Firstly, the various reported tumor markers of breast cancer are introduced. Then, the development of biosensors designed for the sensitive, stable, and selective recognition of breast cancer biomarkers was systematically discussed, with special attention to the main clinical biomarkers, such as human epidermal growth factor receptor-2 (HER2) and estrogen receptor (ER). Finally, the opportunities and challenges of developing efficient biosensors in breast cancer diagnosis and treatment are discussed.

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Section: Biosensormentioning

confidence: 99%

“… Schematic diagram of detecting the CEA protein using fluorescence biosensor-based UCNPs and FRET [ 89 ]. The presence of the target blocked the FRET between the UCNPs and the GO, resulting in the recovery of fluorescence at 546 nm.…”

Section: Figurementioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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“…148 These properties allow improving the LOD and even enabling single molecule detection, making fluorescence-based nanobiosensor devices more sensitive and reliable when compared to the classic fluorescence detection methodologies. Fluorescent NPs include NPs made with silica and organically modified silica, 149 metals, 150 metal oxides, 151 metal nanoclusters, 152,153 upconversion NPs (UCNPs), 154,155 organic polymers, 156 quantum dots (QDs), 157,158 silicon quantum dots 159 and different carbonaceous nanomaterials such as carbon dots, carbon nanotubes, carbon nanoclusters and nanodiamonds. 160,161 Lanthanide-doped UCNPs undergo a non-linear photophysical process whereby low-energy radiation, usually in the near infrared (NIR) range, is converted to higher-energy radiation, for example, visible light (anti-Stokes shift).…”

Section: Np-based Biosensors For Ev Analysismentioning

confidence: 99%

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

et al. 2020

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“…Tumor biomarkers are substances, usually proteins, that are produced specifically in response to cancer developing. There were different biomarkers reported; including carcinoembryonic antigen (CEA), 48 carbohydrate antigen (eg, CA19-9), 49 alpha fetoprotein (AFP), 50 and tumor-associated antigens (eg, prostate-specific membrane antigen, PSMA). 51,52 Tumor-associated antigens are specifically located on cell membrane or in intracellular structure; including epidermal growth factor receptor (EGFR), 53 folate receptor-α (FR-α), 54,55 vascular endothelial growth factor receptor (VEGFR), 56 estrogen receptor (ER), and progesterone receptor (PR).…”

Section: Design Of Up-conversion Nanoprobes For Molecular Imagingmentioning

confidence: 99%

<p>Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment</p>

Wei

et al. 2020

IJN

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In the past few years, we have witnessed great development and application potential of various up-conversion luminescent nanoparticles (UCNPs) in the nanomedicine field. Based on the unique luminescent mechanism of UCNPs and the distinguishable features of cancer biomarkers and the microenvironment, an increasing number of smart UCNPs nanoprobes have been designed and widely applied to molecular imaging, cancer diagnosis, and treatment. Considerable technological success has been achieved, but the main obstacles to oncology nanomedicine is becoming an incomplete understanding of nano-bio interactions, the challenges regarding chemistry manufacturing and controls required for clinical translation and so on. This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on our growing understanding of tumor biology and smart nano-devices for accelerating the commercialization of UCNPs.

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An ultrasensitive homogeneous aptasensor for carcinoembryonic antigen based on upconversion fluorescence resonance energy transfer

Cited by 50 publications

References 36 publications

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

<p>Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment</p>

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