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Cited by 102 publications
(82 citation statements)
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References 31 publications
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“…1) out of a total of several thousand diseases. These predictions for effects of prochloraz on human health are in line with experimental data from rats indicating that the main adverse outcomes after exposure to prochloraz are diseases related to reproductive health [35][36][37][38]. Another pesticide, mancozeb, underwent the same network analysis and was found to be associated with, for example, inflammatory targets and had no targets in common with prochloraz or other tested pesticides [20].…”
Section: A Case Study: Computational Systems Biology Applied On Prochsupporting
confidence: 77%
See 1 more Smart Citation
“…1) out of a total of several thousand diseases. These predictions for effects of prochloraz on human health are in line with experimental data from rats indicating that the main adverse outcomes after exposure to prochloraz are diseases related to reproductive health [35][36][37][38]. Another pesticide, mancozeb, underwent the same network analysis and was found to be associated with, for example, inflammatory targets and had no targets in common with prochloraz or other tested pesticides [20].…”
Section: A Case Study: Computational Systems Biology Applied On Prochsupporting
confidence: 77%
“…Prochloraz is a widely used pesticide that has been demonstrated to have endocrine activity. In animals, it has been shown to cause adverse reproductive outcomes in the male offspring after exposure during foetal life [35][36][37][38]. Prochloraz is known to demasculinize male rat foetuses and virilize female foetuses; however, as clinical studies of environmental chemicals are not carried out, little is known about human effects of this compound.…”
Section: A Case Study: Computational Systems Biology Applied On Prochmentioning
confidence: 99%
“…Further studies are required to clarify these findings. The expression of Cyp17A encoding 17a-hydroxylase/17,20-lyase has been shown to be modulated in fetal testis by V and prochoraz (another fungicide with anti-androgen activity), resulting in changes to androgen metabolism (Laier et al 2006). The modulation of genes involved in steroidogenesis by V at PND35 (see Supplementary Table S2) may reflect changes in estrogen and androgen balance during fetal development.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to antiandrogenic action, prochloraz antagonizes the estrogen receptor, agonizes the aryl hydrocarbon (Ah) receptor and suppresses aromatase activity (Andersen et al, 2002;Vinggaard et al, 2006). Gestational exposure significantly reduces testosterone production by inhibiting activity of cytochrome P450c17, decreases reproductive organ weights, increases nipple retention and induces malformations (e.g., hypospadias) in androgendependent tissues of male offspring Laier et al, 2006;Noriega et al, 2005;Vinggaard et al, 2005). Linuron is a herbicide employed to control of weeds in crops and potatoes (Gray et al, 2006).…”
Section: Flutamide As a Model Antiandrogenmentioning
confidence: 99%