Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up

Edwards, Marjorie; Rotramel, Alizah R.; Beyer, Todd D.; Gaffud, Michael J.; Djuricin, Goldie; Loviscek, K; Solórzano, Carmen C.; Prinz, Richard A.

doi:10.1016/j.surg.2006.06.016

Cited by 84 publications

(15 citation statements)

References 21 publications

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“…However, the procedure had an important beneficial effect, which can be explained by the reduction of the toxic effects of PTH, causing multiple organ damage and exuberant symptomatology 28 . These improvements validate the indication of parathyroidectomy as early as possible in CKD 29,30 . The present study has some limitations that include the low number of participants, due to the financial difficulties of a public hospital, and the lack of information about the body weight gain after PTx.…”

Section: Discussionsupporting

confidence: 62%

Paratireoidectomia na doença renal crônica: efeitos no ganho de peso e na melhora da qualidade de vida

Valente-Da-Silva

Maya

Moreira

2017

Rev. Col. Bras. Cir.

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RESUMO Objetivo: avaliar o benefício de paratireoidectomia em pacientes submetidos à hemodiálise, em relação ao estado nutricional e bioquímico, composição corporal e a qualidade de vida. Métodos: estudo longitudinal envolvendo 28 adultos em programa de hemodiálise, com hiperparatireoidismo secundário grave, avaliados antes e um ano após a cirurgia. Critérios de inclusão: níveis de paratormônio dez vezes superior ao valor de referencia e doença renal crônica em programa de hemodiálise. O índice de massa corporal foi utilizado para classificação do estado nutricional. A bioimpedância elétrica para avaliação da composição corporal. A análise bioquímica incluiu dosagem de lipídios e marcadores do metabolismo ósseo. A qualidade de vida foi avaliada pelo questionário SF36 (Short Form Health Survey). Todos os pacientes foram submetidos à paratireoidectomia total com implante em antebraço. Resultados: houve ganho significativo de peso corporal (61,7 vs 66,0 kg; p<0,001), da massa celular corporal (22,0 vs 24,5 kg/m2; p=0,05) e da qualidade de vida (p=0,001) após a cirurgia. Com relação ao metabolismo ósseo, PTH intacto, cálcio, fósforo e fosfatase alcalina, se estabilizaram e houve melhora em parâmetros bioquímicos, tais como albumina e hemoglobina. Conclusão: a paratireoidectomia melhora a sobrevida em pacientes de hemodiálise e está associada a aumento de peso, ganho de massa óssea e melhoria na qualidade de vida.

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Section: Discussionsupporting

confidence: 62%

Paratireoidectomia na doença renal crônica: efeitos no ganho de peso e na melhora da qualidade de vida

Valente-Da-Silva

Maya

Moreira

2017

Rev. Col. Bras. Cir.

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“…Another area in which our observations are noteworthy is in the postoperative benefits on neuropsychiatric manifestations (8,9,(23)(24)(25)(26). The results of basal SF-36 and SCL-90 questionnaires indicated only a minimal difference when compared with healthy control, nonhyperparathyroid subjects.…”

Section: Discussionmentioning

confidence: 61%

Surgery or Surveillance for Mild Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Clinical Trial

Ambrogini

Cetani

Cianferotti

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

346

284

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Context:It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management. Objective:The aim of the study was to evaluate the beneficial effect of PTx vs. conservative management in patients with mild asymptomatic PHPT. Design:We conducted a prospective, randomized study. Setting:The study took place at a referral center. Patients:We studied 50 patients who did not meet any guidelines for parathyroid surgery as recommended by the National Institutes of Health Consensus Development Conference on Asymptomatic PHPT.Intervention: Patients were randomly assigned to PTx or no PTx and were evaluated at 6 months and at 1 yr. Main Outcome Measures:We compared changes (percentage of basal) of lumbar spine bone mineral density (BMD) between the two groups at 1 yr. Results:The change in BMD at lumbar spine was greater after PTx (ϩ4.16 Ϯ 1.13 for PTx vs. Ϫ1.12 Ϯ 0.71 for no PTx; P ϭ 0.0002). The change in BMD at the total hip was also significantly greater in the PTx group (ϩ2.61 Ϯ 0.71 for PTx vs. Ϫ1.88 Ϯ 0.60 for no PTx; P ϭ 0.0001). There was no difference in BMD after 1 yr between both groups at the one-third radius site. In comparison with those who did not undergo surgery, the PTx subjects, after 1 yr, showed significant differences in four quality of life measures as determined by the 36-item short form health survey scale: bodily pain (P ϭ 0.001), general health (P ϭ 0.008), vitality (P ϭ 0.003), and mental health (P ϭ 0.017). Conclusions:In patients with mild asymptomatic PHPT, successful PTx is followed by an improvement in BMD and quality of life.

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“…Until 1984, the researchers who wanted to evaluate psychological indicators in pHPT have been concentrating on quality of life questionnaires such as SF-36, HSQ (Health Status Questionnaire) [2,[13][14][15][16][17] and a more specific tool for pHPT patients-The Parathyroidectomy Assessment of Symptoms (PAS) [18]. These questionnaires concentrated of symptom-determined aspects of the disease that included: limitations due to physical health condition, pain, general malaise, vitality decrease, limitations in social functions due to emotional problems, and mental health problems [13], but they lacked more subtle evaluation of neuropsychological parameters which may proceed symptomatic presentation of the disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism

Babińska

Barczyński

Stefaniak

et al. 2011

Langenbecks Arch Surg

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Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up

Cited by 84 publications

References 21 publications

Paratireoidectomia na doença renal crônica: efeitos no ganho de peso e na melhora da qualidade de vida

Paratireoidectomia na doença renal crônica: efeitos no ganho de peso e na melhora da qualidade de vida

Surgery or Surveillance for Mild Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Clinical Trial

Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism

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