Production of micro- and nano-composite particles by supercritical carbon dioxide

Bahrami, Mehrangiz; Ranjbarian, S.

doi:10.1016/j.supflu.2006.05.006

Cited by 152 publications

(65 citation statements)

References 65 publications

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“…The rapid expansion of solution through a nozzle results in particles. The consumption of CO 2 in PGSS method is lower than RESS method (11).…”

Section: Introductionmentioning

confidence: 84%

“…A comprehensive review article focused on the production of composite particles by SCF has been reported by Bahrami and Ranjbarian (2007) and classified based on the roles of SCF, which are solvent, anti-solvent, and solute (11). The following are mainly established SCF techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Bahrami and Ranjbarian (2007) and Tandya et al (2007) have reviewed the application of SCF techniques to fabricate polymeric drugloaded formulations (11,26). There were numerous reports of the production of composite particles of drug-loaded biodegradable polymers such as lovastatin-loaded DL-PLA (19), gentamicin-loaded L-PLA (27) and hydrocortisone-loaded DL-PLGA microparticles (28), and tetracosactide-L-PLA microparticles (29).…”

Section: Introductionmentioning

confidence: 99%

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Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

2008

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Abstract. Formation of inhalable microparticles containing rifampicin and poly(L-lactide) (L-PLA) by using supercritical anti-solvent process (SAS) was investigated. The solutions of drug and polymer in methylene chloride were sprayed into supercritical carbon dioxide. The effect of polymer content and operating conditions, temperature, pressure, carbon dioxide molar fraction, and concentration of solution, on product characteristics were studied. The prepared microparticles were characterized with respect to their morphology, particle size and size distribution, drug content, drug loading efficiency, and drug release characteristic. Discrete, spherical microparticles were obtained at high polymer:drug ratios of 7:3, 8:2, and 9:1. The shape of L-PLA microparticles became more irregular and agglomerated with decreasing polymer content. Microparticles with polymer content higher than 60% exhibited volumetric mean diameter less than 5 μm, but percent drug loading efficiency was relatively low. Drug-loaded microparticles containing 70% and 80% L-PLA showed a sustainable drug release property without initial burst release. Operating temperature level influenced on mean size and size distribution of microparticles. The operating pressure and carbon dioxide molar fraction in the range investigated were unlikely to have an effect on microparticle formation. An increasing concentration of feed solution provided larger size microparticles. Rifampicin-loaded L-PLA microparticles could be produced by SAS in a size range suitable for dry powder inhaler formulation.

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“…The rapid expansion of solution through a nozzle results in particles. The consumption of CO 2 in PGSS method is lower than RESS method (11).…”

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

2008

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“…For the extraction of vegetable raw materials, super-critical solutions, in particular carbon dioxide, are used [10]. Such methods of extraction are used in the process of developing technologies for medical preparations, such as nanoand microforms, applying super-critical fluids to obtain them [11]. Super-critical solutions are used when obtaining hard-soluble substances [12][13][14].…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Influence of surface active substances on the intensification of extraction when changing hydrodynamic indices of the technology of organopreparations

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Drachuk

Halukh

et al. 2016

EEJET

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“…Therefore, a fast supersaturation takes place, leading to nucleation and formation of micro or nanoparticles (Sosa et al, 2011). If a coating material is also employed encapsulates are formed by co-precipitation with the solute (Bahrami & Ranjbarian, 2007;Cocero et al, 2009). These processes have several figures of merit, including lower operating temperature than that used in conventional process such as spray drying, and lower residual solvent in the final product.…”

Section: Coupling Of Anti-solvent Precipitation Vessels To Pressurizementioning

confidence: 99%

Developing novel one-step processes for obtaining food-grade O/W emulsions from pressurized fluid extracts: processes description, state of the art and perspectives

Santos

Meireles

2015

Food Sci. Technol

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In this work, a novel on-line process for production of food-grade emulsions containing oily extracts, i.e. oil-in-water (O/W) emulsions, in only one step is presented. This process has been called ESFE, Emulsions from Supercritical Fluid Extraction. With this process, emulsions containing supercritical fluid extracts can be obtained directly from plant materials. The aim in the conception of this process is to propose a new rapid way to obtain emulsions from supercritical fluid extracts. Nowadays the conventional emulsion formulation method is a two-step procedure, i.e. first supercritical fluid extraction for obtaining an extract; secondly emulsion formulation using another device. Other variation of the process was tested and successfully validated originating a new acronymed process: EPFE (Emulsions from Pressurized Fluid Extractions). Both processes exploit the supercritical CO2-essential oils miscibility, in addition, EPFE process exploits the emulsification properties of saponin-rich pressurized aqueous plant extracts. The feasibility of this latter process was demonstrated using Pfaffia glomerata roots as source of saponin-rich extract, water as extracting solvent and clove essential oil, directly extracted using supercritical CO2, as a model dispersed phase. In addition, examples of pressurized fluid-based coupled processes applied for adding value to food bioactive compounds developed in the past five years are reviewed.

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Production of micro- and nano-composite particles by supercritical carbon dioxide

Cited by 152 publications

References 65 publications

Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

Formation of Inhalable Rifampicin–Poly(l-lactide) Microparticles by Supercritical Anti-solvent Process

Influence of surface active substances on the intensification of extraction when changing hydrodynamic indices of the technology of organopreparations

Developing novel one-step processes for obtaining food-grade O/W emulsions from pressurized fluid extracts: processes description, state of the art and perspectives

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