2016
DOI: 10.1016/j.str.2016.04.013
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Peroxiredoxins are antioxidant proteins primarily responsible for detoxification of hydroperoxides in cells. On exposure to various cellular stresses, peroxiredoxins can acquire chaperone activity, manifested as quaternary reorganization into a high molecular weight (HMW) form. Acidification, for example, causes dodecameric rings of human peroxiredoxin 3 (HsPrx3) to stack into long helical filaments. In this work, a 4.1-Å resolution structure of low-pH-instigated helical filaments was elucidated, showing a loc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
47
0

Year Published

2017
2017
2020
2020

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 41 publications
(50 citation statements)
references
References 55 publications
3
47
0
Order By: Relevance
“…The observed outer diameter of the CrPRX1 ring was 16.8 AE 0.94 nm (n = 30) on average. Together with the observed fivefold symmetry and the experimentally measured height and diameter of CrPRX1, the possibility of a highly stacked ring structure, as found in the filamentous oligomeric state of PRX3 (Yewdall et al, 2016), is unlikely. Although the only available structure of a plant PRX (that from P. trichocapa) is homodimeric (PDB entry 2pwj; Barranco-Medina et al, 2006), the search model for molecular replacement with the highest sequence identity (PDB entry 1qmv) possessed a decameric ring structure.…”
Section: Resultsmentioning
confidence: 88%
See 1 more Smart Citation
“…The observed outer diameter of the CrPRX1 ring was 16.8 AE 0.94 nm (n = 30) on average. Together with the observed fivefold symmetry and the experimentally measured height and diameter of CrPRX1, the possibility of a highly stacked ring structure, as found in the filamentous oligomeric state of PRX3 (Yewdall et al, 2016), is unlikely. Although the only available structure of a plant PRX (that from P. trichocapa) is homodimeric (PDB entry 2pwj; Barranco-Medina et al, 2006), the search model for molecular replacement with the highest sequence identity (PDB entry 1qmv) possessed a decameric ring structure.…”
Section: Resultsmentioning
confidence: 88%
“…In the crystal structure, the human homologues of 2-Cys PRX, peroxiredoxin 3 (PRX3; PDB entry 5jcg) and peroxiredoxin 4 (PRX4; PDB entry 3tkp), form decamers (Yewdall et al, 2016;Wang et al, 2012). The cryo-TEM structure of PRX3 shows that decameric ring structures are stacked into a long helical filament, which might function as a self-associating chaperone.…”
Section: Introductionmentioning
confidence: 99%
“…As can be seen this is a case that could also be included in the preceding section. f. Human Peroxiredoxin 3, PDBid: 5JCG, [26]. This structure is a microtubule formed by stacked rings that serve as basic elements of growth.…”
Section: Helicoidal Growth and Microtubulesmentioning
confidence: 99%
“…Small differences in the locations of the hydrophobic centroids of the six components of each ring provokes a small asymmetry that gives rise to this vector H within the plane of the hexamer. Authors in [26] A common feature of self-assembling shared by these systems is determined by the fact that besides the proposed hydrophobic interaction forcing the individual H vectors to align according to the "membrane model", the complexity of the structure and the importance of the individual D vectors, prevent a perfect alignment of the basic elements, forcing the assembly to adopt curvatures and slanted lateral stacking, ending up in a helical conformation.…”
Section: Helicoidal Growth and Microtubulesmentioning
confidence: 99%
“…Depending on the redox state, typical 2‐Cys Prxs can form more complex quaternary structures . Most of them exist as a dimer or decamer, with two different interfaces called A‐ and B‐type dimeric interfaces, depending on the redox conditions .…”
mentioning
confidence: 99%