Hexabromocyclododecanes in breast milk from residents in Shenzhen, China: Implications for infant exposure

Lu, Shaoyou; Tan, Zhen; Jiang, Yousheng; Wu, Dongting; Jian, Zhou; Lin, Xiaoshi

doi:10.1016/j.scitotenv.2017.11.277

Cited by 18 publications

(1 citation statement)

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“…The rst detection of environmental HBCDs was in sh and sediment samples from the river Viskan in Sweden, 1995 (Sellström et al 1998). Since then, they have been found in various environmental media (Cao et al 2018), even in the human body (Lu et al 2018;Roosens et al 2009). Since HBCDs were recalcitrant to degradation and could lead to neurotoxicity (Mariussen and Fonnum et al 2003), disruption of the in ammatory response in the immune cells (Yasmin and Whalen et al 2018) and the bronchial epithelial cells (Koike et al 2016), they had been listed in Annex A of the Stockholm Convention on Persistent Organic Pollutants (POPs) in May 2013.…”

Section: Introductionmentioning

confidence: 99%

Biotransformations of HBCDs by Rhodococcus Strain Stu-38 and Identification of Transformation Products

Yu¹,

Luo²,

Li³

et al. 2021

Preprint

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1, 2, 5, 6, 9, 10-Hexabromocyclododecanes (HBCDs) are new brominated flame retardants causing serious environmental pollution. Dozens of degradative bacteria have been found with capacity to transform HBCDs. In the present study, an aerobic functional bacterium Rhodococcus strain stu-38 was isolated from enriched culture of mangrove sediment using HBCDs as carbon source. This strain could stereoselectively transform HBCDs, the removal rate was α-＞γ-＞β-HBCD in the mineral salt medium, but was β-＞α- and γ-HBCD in the growth medium, and it selectively transformed γ- HBCD in the seawater. Transformation rate of strain stu-38 was lower than other functional strains, however, seven potential debrominated products of HBCDs were identified by using GC-MS. These debrominated products, included dibromocyclododecadiene, bromocyclododecadienol and bromocyclododecatriene were formed through reductive debromination, hydrolytic debromination and dehydrobromination. Overall, Rhodococcus sp. stu-38 diastereoisomer-specifically transformed HBCDs to various debrominated products in the different cultural media, which highlighted the complicated stereoselective biotransformation of HBCDs.

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