Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins (Carassius auratus)

Zaccaroni, Annalisa; Gamberoni, Matteo; Mandrioli, Luciana; Sirri, Rubina; Mordenti, Oliviero; Scaravelli, Dino; Sarli, Giuseppe; Parmeggiani, Albamaria

doi:10.1016/j.scitotenv.2009.01.036

Cited by 40 publications

(20 citation statements)

References 48 publications

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“…Pesticides usually cause endocrine disruption of the hypothalamicpituitary-thyroid axis (HPT axis) (Tian, Li, Wang, Wu & Ru, 2012;Tian, Ru, Bing & Wang, 2010). The changes in endocrine systems are not probably to be limited to the disruption of one axis, but they can also have significant effects on the other axis especially thyroid hormones (THs) (Zaccaroni et al, 2009). Indoxacarb as an oxadiazin pesticide might have this effect.…”

Section: Plasma Thyroid Hormonesmentioning

confidence: 99%

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

et al. 2017

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Indoxacarb is a relatively new pesticide from oxadiazin class, which is used near carp ponds for agricultural purposes. Thus, the aim of this study was to determine indoxacarb effects on common carp (Cyprinus carpio). The fish were exposed to 0 (control), 0.75, 1.5 and 3 ppm of indoxacarb over 21 days and plasma biochemical characteristics and liver histopathology were examined. Exposure to indoxacarb induced fall in total protein after 21 days. Globulin increased after 7 days and then decreased after 14‐ and 21‐day exposure. Plasma alanine transaminase and aspartate transaminase activities increased in 1.5 and 3 ppm treatments after 7‐day exposure. Indoxacarb exposure significantly decreased plasma alkaline phosphatase after 7 days with no change at the second and third samplings. After 7 days, plasma T3 levels had no significant change; however, it decreased after 14 days in the 1.5 and 3 ppm treatments and also reduced after 21‐day exposure to the 3 ppm treatment compared to the control group. Plasma T4 level only decreased significantly in the 3 ppm treatment compared to the control group after 21 days. Different histopathological symptoms such as necrosis, hyperaemia, sinusoidal space extension, pyknotic nuclei, leucocyte infiltration and melanomacrophage aggregates were observed after 21‐day exposure to indoxacarb. The symptoms intensity was dependent on indoxacarb concentration. In conclusion, the present results show that indoxacarb exposure adversely affects common carp health and welfare, which consequently may induce serious problems in this species aquaculture.

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Section: Plasma Thyroid Hormonesmentioning

confidence: 99%

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

et al. 2017

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“…In the aquatic environment NPE breaks down to 4-nonylphenol (NP), which is more stable and persistent (Guenther et al, 2006;Rivero et al,2008). NP has been reported as estrogenic, toxic and carcinogenic effects in various teleost fish species, birds and mammals, and enhanced resistance towards biodegradation, potential ability to bio-accumulate in a aquatic organisms ( Cionna et al, 2006;Ishibashi et al, 2006;Popek et al, 2006;Vetillard and Bailhache,2006;Yang et al, 2008;Zaccaroni et al, 2009).It is also recorded to accumulate in the internal organs of many fish and avian species, reaching its concentration 10-100 times higher. It is of course the public and scientific issue because it passes down to humans though the food chain.…”

Section: Introductionmentioning

confidence: 99%

A study on the toxicity of 4-nonylphenol on the histopathology of testes of African catfish Clarias gariepinus (Burchell, 1822)

Zade

Nagwanshi

Shinkhede³

et al. 2018

JANS

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In the present study, the effects of long term exposure (5 and 10 days) of 100 µg/lit 4-NP (nonyphenol) on the testis were investigated in African catfish Clarias gariepinus (Burchell, 1822). Histological examination of the testis of fish treated with 100 µg/lit 4-NP for 5 days showed the disintegration of cysts, separation of cells within the cysts, hypertrophy of sertoli cells and vaccuolation in testis. Histological examination of the testis of fish exposed to 100 µg/lit for 10 days showed alteration in structure of the primary spermatocytes. The structure of the spermatocytes changed from spherical to sickle shaped. Hypertrophy of sertoli cell, severe destruction of germ cells (spermatogonia), and vacuole formation was also seen. The study indicated that 4-nonylphenol had marked effects on the histology of testis of C. gariepinus. The severity of effects of fish increased with the time of exposure and it was noticed that there were marked structural changes in the testis exposed to 4-Nonylphenol for long term exposure.

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“…Depending on the endocrine endpoints, they can be estrogenic, androgenic, or thyroidal compounds [32][33][34]. Although the disruption of the androgen and thyroid functions might exerts greater or equal impacts on the environment, most research studies so far have focused on estrogenic EDCs [33]. Thus, EDCs are often referred to as estrogenic EDCs (e-EDCs) in the various studies [34].…”

Section: Definition and Characteristics Of Edcsmentioning

confidence: 99%

“…Many assays for estrogens, using fish, have been developed, such as those for rainbow trout (Oncorhynchus mykiss), fathead minnow (Pimephales promelas), sheephead minnow (Cyprinodon variegates), and zebrafish (Brachydanio rerio) [63,[71][72][73][74][75]. Some genetically engineered species that respond to EDCs, such as transgenic zebrafish (Brachydanio rerio) that have been bioengineered with luciferase expression coordinated to vitellogenin production [63] and medaka fish (Oryzias latipes) or shubunkins (Carassius auratus) designed to express a green fluorescence protein in response to vitellogenin production, have also been ultilized [33,76].…”

Section: Whole Organism Assaysmentioning

confidence: 99%

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Chang

Choo

Lee

et al. 2009

Journal of Hazardous Materials

336

134

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Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins (Carassius auratus)

Cited by 40 publications

References 48 publications

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

Plasma proteins, hepatic enzymes, thyroid hormones and liver histopathology of Cyprinus carpio (Linnaeus, 1758) exposed to an oxadiazin pesticide, indoxacarb

A study on the toxicity of 4-nonylphenol on the histopathology of testes of African catfish Clarias gariepinus (Burchell, 1822)

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

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