2015
DOI: 10.1016/j.rpped.2015.03.009
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Abstract: Objective:To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity.Methods:Cross-sectional study with 245 children and adolescents (134 obese and 111 controls), aged 8-18 years. The anthropometric variables (weight, height and waist circumference), blood pressure and biochemical parameters were collected. The clinical characteristics of the groups were analyzed by t-test or chi-square test. To evaluate the association between uric acid levels… Show more

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Cited by 16 publications
(7 citation statements)
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“…The present study found that insulin level and HOMA-IR correlated positively with serum uric acid level, which is consistent with previous studies (Gill et al, 2013; de Miranda et al, 2015). Insulin resistance probably contributes hyperuricemia through either lower renal excretion, higher synthesis or both (de Oliveira and Burini, 2012).…”
Section: Discussionsupporting
confidence: 94%
“…The present study found that insulin level and HOMA-IR correlated positively with serum uric acid level, which is consistent with previous studies (Gill et al, 2013; de Miranda et al, 2015). Insulin resistance probably contributes hyperuricemia through either lower renal excretion, higher synthesis or both (de Oliveira and Burini, 2012).…”
Section: Discussionsupporting
confidence: 94%
“…Uric acid has a relevant positive correlation with BMI, AC and insulin levels. Miranda et al 30 correlated increased serum uric acid levels with insulin resistance and found that increase of 1 mg/dL in serum uric acid levels was responsible for a 91% increase in chance of developing insulin resistance. Although there the literature is not consensual as to reference values of this marker in children and adolescents, uric acid dosage appears to be a good predictor of cardiometabolic risk in young age groups.…”
Section: Discussionmentioning
confidence: 99%
“…Although there the literature is not consensual as to reference values of this marker in children and adolescents, uric acid dosage appears to be a good predictor of cardiometabolic risk in young age groups. 30 …”
Section: Discussionmentioning
confidence: 99%
“…Second, another possible explanations for this relationship is that insulin resistance is the link between GH and uric acid. Hyperuricemia is suggested to be associated with insulin resistance 20 . Recent studies found that high uric acid directly inhibited insulin signal and induces insulin resistance 21 .…”
Section: Discussionmentioning
confidence: 99%