2017
DOI: 10.1016/j.rbre.2017.03.002
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Abstract: Gout is considered the most common form of inflammatory arthritis in men over 40 years. The authors present a brief review of the current treatment of gout and discuss the existing pharmacological limitations in Brazil for the treatment of this disease. Although allopurinol is still the main drug administered for decreasing serum levels of uric acid in gout patients in this country, the authors also present data that show a great opportunity for the Brazilian drug market for the treatment of hyperuricemia and … Show more

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Cited by 6 publications
(8 citation statements)
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“…Maximum patients (i.e., 266, 69.3%) aged 34 to 63 years were suffering from low risk of progression to CKD with gout, and the high risk increased in the age range 54-63 and ≥ 84 years by 17 and 43 times, respectively. The finding was in line with various published findings that gout mainly affects men over the age of 40 years [6,7,14,[25][26][27]. Such slight variation might be due to the inclusion of all age groups in the present research.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Maximum patients (i.e., 266, 69.3%) aged 34 to 63 years were suffering from low risk of progression to CKD with gout, and the high risk increased in the age range 54-63 and ≥ 84 years by 17 and 43 times, respectively. The finding was in line with various published findings that gout mainly affects men over the age of 40 years [6,7,14,[25][26][27]. Such slight variation might be due to the inclusion of all age groups in the present research.…”
Section: Discussionsupporting
confidence: 93%
“…Gouty arthritis and tophi may lead to chronic disability, impair health-related quality of life (HRQoL), increase healthcare resources and reduce productivity [2][3][4]. Gout has prevalence of 1.14%, 1.7%, 2.49%, 2.7% and 4% in China, Australia, UK, New Zealand, and US respectively [1,3,5,6] and its prevalence is rising every year both in developing and developed countries due to various factors such as high BMI (as obesity increases endogenous uric acid production), and concomitant diseases (e.g., hypertension), consumption of purine-rich diets (e.g., red meat, high-fructose syrup or beverage, beer, seafood), and medications (e.g., diuretics, cyclosporine) [4,6,[7][8][9][10]. Countrywide gout prevalence is understudied domain in Nepal like other developing countries [11], and one research found a district-wise prevalence of 21.42% at Chitwan district, one of the districts out of 13 in Bagmati Province in Nepal [12].…”
Section: Introductionmentioning
confidence: 99%
“…The high risk of progression increased in the age range 54-63 and �84 years by 17 and 43 times, respectively. The finding was in line with the various published findings that gout mainly affects men over the age of 40 years [6,7,14,[25][26][27]. Such slight variation might be due to the inclusion of all age groups in the present research.…”
Section: Discussionsupporting
confidence: 93%
“…Gout has prevalence of 1.14%, 1.7%, 2.49%, 2.7% and 4% in China, Australia, UK, New Zealand, and the USA respectively [1,3,5,6]. Its prevalence is rising every year both in the developing and the developed countries due to various factors such as high body mass index (BMI) (as obesity increases endogenous uric acid production), and concomitant diseases (e.g., hypertension), consumption of purine-rich diets (e.g., red meat, high-fructose syrup or beverage, beer, seafood), and medications (e.g., diuretics, cyclosporine) [4,6,[7][8][9][10]. Country-wise gout prevalence is understudied domain in Nepal like other developing countries [11], and district-wise prevalence was found to be 21.42% at Chitwan district, one of 76 districts in Nepal [12].…”
Section: Introductionmentioning
confidence: 99%
“…Several isolated aromatic herbs from plants, medicinal plants, www.ajpp.in Figure 3. Pharmacotherapy for controlling hyperuricemia and how they react within normal physiological condition within the human body (Azevedo et al, 2017) vegetables, fruits, cereals, nuts, legumes, seeds, spices, green and black tea hold oxygen scavenging capacity to obliterate the oxidation and inflammation reaction formed through enzyme xanthine oxidase. To dam, the formation of uric acid XO is clogged by active constituents of plant metabolites and via hydrophobic bonds produced XO-active metabolites composite besides blocked the free active site that dosen't allow additional binding.…”
Section: Underexcretion Of Uric Acidmentioning
confidence: 99%