Obesity is the main determinant of insulin resistance more than the circulating pro-inflammatory cytokines levels in rheumatoid arthritis patients

Castillo-Hernández, Jesús; Maldonado‐Cervantes, Martha Imelda; Reyes, Juan Pablo; Patiño-Marín, Nuria; Maldonado‐Cervantes, Enrique; Solorzano‐Rodriguez, Claudia; Mendoza, Esperanza de la Cruz; Alvarado‐Sánchez, Brenda

doi:10.1016/j.rbre.2017.01.008

Cited by 11 publications

(9 citation statements)

References 47 publications

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“…comorbidity even on first presentation of RA [21] and is a key determinant of insulin resistance, even more so than circulating proinflammatory cytokines [25].…”

Section: Co-morbidities Related To Diet As Disease 'Triggers'mentioning

confidence: 99%

Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis

Philippou

Nikiphorou

2018

Autoimmunity Reviews

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Accumulating research evidence suggests that individual dietary factors and dietary patterns might be implicated in the risk of development of rheumatoid arthritis (RA). This narrative review aims to present this evidence and provide nutritional recommendations for reducing RA risk in susceptible individuals. Overall, a 'Western' type diet rich in energy intake, total and saturated fat, an unbalanced ratio of n-3 to n-6 fatty acids, high in refined carbohydrates and sugar and low in fiber and antioxidants might increase the risk of RA both directly through increasing inflammation and indirectly through increasing insulin resistance and obesity, with the latter being a known risk factor for RA. On the contrary, consumption of long-chain omega-3 polyunsaturated fatty acids, derived from fish and fish oil, is associated with a reduced risk of RA probably due to their anti-inflammatory properties. The Mediterranean diet (MD), rich in plant-based foods such as wholegrains, legumes, fruit, vegetables, extra-virgin olive oil and low in red meat consumption, might have the potential to reduce the risk of RA. Based on current research evidence, it is suggested that adherence to the MD enhanced with an increased consumption of fatty fish, reduced consumption of sugar-sweetened drinks and maintenance of a normal body weight, contributes to reducing the risk of RA. Further research on RA susceptibility will allow for more specific dietary recommendations to be made.

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“…comorbidity even on first presentation of RA [21] and is a key determinant of insulin resistance, even more so than circulating proinflammatory cytokines [25].…”

Section: Co-morbidities Related To Diet As Disease 'Triggers'mentioning

confidence: 99%

Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis

Philippou

Nikiphorou

2018

Autoimmunity Reviews

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“…[17][18][19][20][21] Waist circumference, BMI and obesity seem to be the main factors contributing to increased insulin resistance in these diseases. 22,23 For instance, BMI and waist circumference were found to be significantly associated with the HOMA2-IR in systemic lupus erythematosus. 22 In rheumatoid arthritis, obesity is the main determinant of insulin resistance, even more than the circulating pro-inflammatory cytokines levels.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…22,23 For instance, BMI and waist circumference were found to be significantly associated with the HOMA2-IR in systemic lupus erythematosus. 22 In rheumatoid arthritis, obesity is the main determinant of insulin resistance, even more than the circulating pro-inflammatory cytokines levels. 23 The present study corroborates the growing body of evidence suggesting that insulin resistance in autoimmune rheumatic diseases is independent of the diseases and is, instead, caused by associated risk factors.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…23 The present study corroborates the growing body of evidence suggesting that insulin resistance in autoimmune rheumatic diseases is independent of the diseases and is, instead, caused by associated risk factors. 22,23 Several factors can contribute to the high BMI and waist circumference found in these patients. The use of glucocorticoids could be associated with an increase in visceral fat and waist circumference.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Insulin resistance is increased in adult patients with dermatomyositis

Oliveira¹,

Guimarães²,

Shinjo³

2018

Medical Express

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OBJECTIVE: To evaluate insulinemia in glucocorticoid naïve patients with dermatomyositis and to evaluate insulin resistance using the homeostatic model assessment of insulin resistance (HOMA2-IR). METHODS: This cross-sectional study included 25 dermatomyositis, non-diabetic glucocorticoid naïve patients. The control group consisted of 50 volunteers matched for age, gender, ethnicity, weight and height. The HOMA2-IR index was calculated from baseline insulin and glucose data. The International Myositis Assessment & Clinical Studies Group (IMACS) parameters were used to evaluate disease status. RESULTS: Mean age of the patients was 43.5 years and these were predominantly females. Patients had low disease activity according to IMACS parameters. Higher body mass index and waist circumference were observed in the dermatomyositis group compared to the control group. Insulin level and HOMA2-IR were also higher in patients with dermatomyositis. Moreover, analyzing dermatomyositis alone, the HOMA2-IR index correlated positively with weight, body mass index and waist circumference and was independent on disease status parameters. CONCLUSIONS: Patients with dermatomyositis had higher values for basal insulinemia, insulin resistance, body mass index and waist circumference. Moreover, HOMA2-IR moderately correlated with these anthropometric parameters. These metabolic abnormalities are related to the development of metabolic syndrome, one of the main comorbidities observed in dermatomyositis.

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“… 12 13 In addition, obesity, a global health problem, represents an important and rising comorbidity even on first presentation of RA 14 and appears to be a key determinant of insulin resistance, even more so than circulating proinflammatory cytokines. 15 …”

Section: State Of Knowledgementioning

confidence: 99%

Don’t neglect nutrition in rheumatoid arthritis!

Cutolo

Nikiphorou

2018

RMD Open

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Obesity is the main determinant of insulin resistance more than the circulating pro-inflammatory cytokines levels in rheumatoid arthritis patients

Abstract: Obesity appears to be a dominant condition above inflammation to produce IR in RA patients. The dissociation of the inflammation and obesity components to produce IR suggests the need of an independent therapeutic strategy in obese patients with RA.

Cited by 11 publications

References 47 publications

Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis

Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis

Insulin resistance is increased in adult patients with dermatomyositis

Don’t neglect nutrition in rheumatoid arthritis!

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